Glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: pathophysiologic foundation and clinical findings.


Journal Article (Review)

The pathophysiologic basis for potent platelet inhibition in the acute coronary syndromes has been established. In the setting of PTCA for unstable angina and non-Q-wave myocardial infarction, there are clear data for a benefit of GP IIb/IIIa inhibition, whereas for primary PTCA in evolving myocardial infarction, preliminary data are very encouraging and a large-scale clinical trial is nearly completed. Glycoprotein IIb/IIIa inhibition as an adjunct to medical therapy for unstable angina is also the subject of encouraging preliminary data, and 3 large-scale clinical trials have just been completed. Preliminary data have also been accrued for GP IIb/IIIa inhibition as conjunctive therapy with thrombolytic agents, and large clinical trials are now commencing.

Full Text

Duke Authors

Cited Authors

  • Kleiman, NS; Lincoff, AM; Ohman, EM; Harrington, RA

Published Date

  • October 1998

Published In

Volume / Issue

  • 136 / 4 Pt 2 Su

Start / End Page

  • S32 - S42

PubMed ID

  • 9778086

Pubmed Central ID

  • 9778086

International Standard Serial Number (ISSN)

  • 0002-8703

Digital Object Identifier (DOI)

  • 10.1053/hj.1998.v136.93434


  • eng

Conference Location

  • United States