Characteristics of creatine kinase-MB and MB isoforms in serum after reperfusion in acute myocardial infarction.

Published

Journal Article

Characteristics of CK-MB, the MB1 and MB2 isoforms, and the MB2/MB1 ratio are described in six acute myocardial infarction (AMI) patients in whom the infarct-related artery was identified and, after intervention, normal coronary flow was re-established. After myocardial reperfusion, washout of CK-MB and the MB2 isoform occurred in parallel, with CK-MB peaking between 5.75 and 10.0 h, and MB2 peaking between 4.50 and 8.00 h. In five of the six patients, MB1 peaked between 8.75 and 15.5 h; the MB2/MB1 ratio demonstrated the earliest peak from 0.75 to 2.25 h. When we compared this study group to an additional 10 AMI patients who had achieved myocardial reperfusion earlier, we found a significant difference (P less than 0.005) for all tests, except MB1 isoform activity, as early as 50 min after reperfusion. This same comparison, by logistic-regression analysis, showed that the MB2/MB1 ratio discriminated between the groups 50 min after reperfusion (P less than 0.05); MB2 showed near-significance at 100 min (P less than 0.057); and CK-MB achieved significance after 200 min (P less than 0.05). CK-MB, the MB2 isoform, and especially the MB2/MB1 ratio show potential for the early, noninvasive detection of myocardial reperfusion.

Full Text

Duke Authors

Cited Authors

  • Christenson, RH; Ohman, EM; Clemmensen, P; Grande, P; Toffaletti, J; Silverman, LM; Vollmer, RT; Wagner, GS

Published Date

  • November 1989

Published In

Volume / Issue

  • 35 / 11

Start / End Page

  • 2179 - 2185

PubMed ID

  • 2582613

Pubmed Central ID

  • 2582613

Electronic International Standard Serial Number (EISSN)

  • 1530-8561

International Standard Serial Number (ISSN)

  • 0009-9147

Language

  • eng