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Beta-adrenoceptor adaptation to endurance training.

Publication ,  Journal Article
Ohman, EM; Butler, J; Kelly, J; Horgan, J; O'Malley, K
Published in: J Cardiovasc Pharmacol
December 1987

Endurance exercise is associated with various cardiovascular adaptations, and these may include changes in sympathoadrenal activity and end-organ responsiveness to norepinephrine (NE). Because beta-adrenoceptor function is a major determinant of sympathetic responsiveness, we used the lymphocyte beta-adrenoceptor as a model to study the effects of endurance training in 19 male subjects before, during, and after preparation for a marathon race. Before the subjects trained, resting beta-adrenoceptor density was positively correlated to resting heart rate (r = 0.47, p less than 0.05) but this correlation was not evident after training. Eleven of the 19 subjects completed the 3 1/2-month training period, and mean (+/- 1 SD) resting beta-adrenoceptor density fell from 1,593 +/- 333 to 1,197 +/- 332 sites per cell (p less than 0.02) after the training period. Two weeks after cessation of training, receptor density was at pretraining values of 1,547 +/- 209 sites per cell. During training, the subjects ran two 21-km races. Each of these was associated with decreases in beta-adrenoceptor density. Our results demonstrate the episodes of endurance running result in reductions in lymphocyte beta-adrenoceptor density. We conclude that down-regulation of beta-adrenoceptors is an important component of the response to endurance training.

Duke Scholars

Published In

J Cardiovasc Pharmacol

ISSN

0160-2446

Publication Date

December 1987

Volume

10

Issue

6

Start / End Page

728 / 731

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Physical Endurance
  • Physical Education and Training
  • Middle Aged
  • Male
  • Lymphocytes
  • Humans
  • Heart Rate
  • Cardiovascular System & Hematology
  • Adult
 

Citation

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Ohman, E. M., Butler, J., Kelly, J., Horgan, J., & O’Malley, K. (1987). Beta-adrenoceptor adaptation to endurance training. J Cardiovasc Pharmacol, 10(6), 728–731.
Ohman, E. M., J. Butler, J. Kelly, J. Horgan, and K. O’Malley. “Beta-adrenoceptor adaptation to endurance training.J Cardiovasc Pharmacol 10, no. 6 (December 1987): 728–31.
Ohman EM, Butler J, Kelly J, Horgan J, O’Malley K. Beta-adrenoceptor adaptation to endurance training. J Cardiovasc Pharmacol. 1987 Dec;10(6):728–31.
Ohman, E. M., et al. “Beta-adrenoceptor adaptation to endurance training.J Cardiovasc Pharmacol, vol. 10, no. 6, Dec. 1987, pp. 728–31.
Ohman EM, Butler J, Kelly J, Horgan J, O’Malley K. Beta-adrenoceptor adaptation to endurance training. J Cardiovasc Pharmacol. 1987 Dec;10(6):728–731.

Published In

J Cardiovasc Pharmacol

ISSN

0160-2446

Publication Date

December 1987

Volume

10

Issue

6

Start / End Page

728 / 731

Location

United States

Related Subject Headings

  • Receptors, Adrenergic, beta
  • Physical Endurance
  • Physical Education and Training
  • Middle Aged
  • Male
  • Lymphocytes
  • Humans
  • Heart Rate
  • Cardiovascular System & Hematology
  • Adult