Hemodynamic effects of new intra-aortic balloon counterpulsation timing methods in patients: a multicenter evaluation.
(Clinical Trial;Journal Article;Multicenter Study)
BACKGROUND: To test whether later intra-aortic balloon pump (IABP) deflation approaching or simultaneous with left ventricular ejection would improve hemodynamics and myocardial efficiency with the use of new balloon deflation methods, 4 IABP timing techniques were evaluated in 43 patients. METHODS AND RESULTS: Later balloon deflation produced significantly greater percentage changes in mean aortic pressure (6% vs 1%), systolic pressure time index (-27% vs -20%), diastolic pressure time index (35% vs 19%), and the systolic pressure-time index/diastolic pressure-time index ratio (97% vs 51%), respectively. However, these changes increased peak systolic pressure (-15% vs -11%). Cardiac output and stroke volume indexes were not significantly altered over the 4 settings. CONCLUSIONS: These data suggest that systemic hemodynamics and myocardial efficiency may be improved by later balloon deflation approaching left ventricular ejection in comparison to conventional IABP timing.
Kern, MJ; Aguirre, FV; Caracciolo, EA; Bach, RG; Donohue, TJ; Lasorda, D; Ohman, EM; Schnitzler, RN; King, DL; Ohley, WJ; Grayzel, J
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