Use of glycoprotein IIb/IIIa inhibition plus fibrinolysis in acute myocardial infarction.

Journal Article (Journal Article;Review)

Pharmacological reperfusion therapy for acute myocardial infarction with intravenous fibrinolytic agents improves survival yet fails to achieve early and complete coronary blood flow in nearly half of treated patients. In principle, glycoprotein (GP) IIb/IIIa inhibitors, potent antiplatelet agents, might improve the efficacy and clinical outcomes associated with fibrinolysis. Preclinical research suggests more rapid and effective reperfusion with combined platelet GP IIb/IIIa inhibition and fibrinolysis. Early clinical studies confirm improved early patency and more rapid electrocardiographic resolution, but increased bleeding complications, with the addition of GP IIb/IIIa antagonists to conventional fibrinolysis. Future studies may combine reduced-dose fibrinolytic therapy with GP IIb/IIIa inhibition to optimize efficacy and safety.

Full Text

Duke Authors

Cited Authors

  • Hudson, MP; Greenbaum, AB; Harrington, RA; Ohman, EM

Published Date

  • June 1999

Published In

Volume / Issue

  • 7 / 3

Start / End Page

  • 241 - 245

PubMed ID

  • 10373717

International Standard Serial Number (ISSN)

  • 0929-5305

Digital Object Identifier (DOI)

  • 10.1023/a:1008974909124


  • eng

Conference Location

  • Netherlands