[Serum creatine kinase isoenzyme MB and myoglobin in patients with acute myocardial infarction and coronary reperfusion].

Journal Article (Clinical Trial;English Abstract;Journal Article)

Thrombolytic therapy in patients with acute myocardial infarction (AMI) changes the time-concentration curve of serum creatine kinase isoenzyme MB (CK-MB) and serum myoglobin. In this study, 60 AMI patients received thrombolytic therapy and acute coronary arteriography, or conservative treatment. Group one (n = 32) demonstrated a patent infarct-related artery after intravenous thrombolytic therapy; group two (n = 17) had an initially occluded coronary artery which became patent during catheterisation; group three (n = 11) did not receive thrombolytic therapy. Frequent serum CK-MB and myoglobin measurements showed that patients with acute coronary reperfusion had a rapid increase, an earlier peak value and less total release of both CK-MB and myoglobin to blood compared to AMI patients treated conservatively. The changes in serum myoglobin compared to CK-MB demonstrated an even more rapid, more uniform, and relatively greater increase. Measurements of serum myoglobin may be a useful non-invasive method for evaluation of thrombolytic therapy in AMI patients.

Full Text

Duke Authors

Cited Authors

  • Jurlander, B; Clemmensen, PM; Ohman, EM; Wagner, GS; Grande, P

Published Date

  • September 21, 1992

Published In

Volume / Issue

  • 154 / 39

Start / End Page

  • 2682 - 2686

PubMed ID

  • 1413198

International Standard Serial Number (ISSN)

  • 0041-5782


  • dan

Conference Location

  • Denmark