Reduced thrombus burden with abciximab delivered locally before percutaneous intervention in saphenous vein grafts.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

BACKGROUND: Existing thrombus can complicate percutaneous saphenous vein graft (SVG) intervention. Local delivery of thrombolytics has been used to reduce the thrombus burden often associated with these interventions. We sought to determine whether local delivery of a platelet glycoprotein IIb/IIIa inhibitor is feasible and can reduce thrombus burden before percutaneous SVG intervention. METHODS: We performed a multicenter pilot study of abciximab (0.25 mg/kg) given by local delivery catheter before percutaneous intervention for de novo SVG stenoses followed by intravenous infusion. All patients (n = 58) had >/=60% stenosis and Thrombolysis In Myocardial Infarction (TIMI) grade >0 flow in an SVG of 3 to 4 mm in diameter. Percent diameter stenosis, TIMI thrombus grade, and TIMI flow grade were measured before and after delivery of abciximab and after intervention. RESULTS: Median percent diameter stenosis improved from 69% to 45% (P =.0001) after local delivery, and TIMI thrombus grade >/=1 incidence reduced from 68% to 34% (P =.0001). TIMI flow grade was not significantly affected (P =.12). All patients had a successful intervention (

Full Text

Duke Authors

Cited Authors

  • Barsness, GW; Buller, C; Ohman, EM; Schechter, E; Pucillo, A; Taylor, MA; Miller, MJ; Reiner, JS; Churchill, D; Chandler, AB; Gonzalez, M; Smith, J; Tommaso, C; Berdan, LG; Wildermann, NM; Hasdai, D; Holmes, DR

Published Date

  • May 2000

Published In

Volume / Issue

  • 139 / 5

Start / End Page

  • 824 - 829

PubMed ID

  • 10783216

International Standard Serial Number (ISSN)

  • 0002-8703

Digital Object Identifier (DOI)

  • 10.1016/s0002-8703(00)90014-0


  • eng

Conference Location

  • United States