Effectiveness and safety of abciximab after failed thrombolytic therapy.

Published

Journal Article

Among 214 patients treated with abciximab within 24 hours of full-dose thrombolytic therapy, major bleeding occurred in 50 patients (23%; 95% confidence interval [CI] 18% to 30%) and intracranial hemorrhage occurred in 3 patients (1.4%; 95% CI 0.3% to 4%). The independent multivariate predictors of major bleeding were age (odds ratio [OR] 1.53/10 years, 95% CI 1.05 to 2.21, p = 0.03), time from thrombolytic to abciximab (OR 0.91/hour, 95% CI 0.83 to 0.99, p = 0.03), and intra-aortic balloon pump insertion (OR 4.42, 95% CI 2.00 to 9.72, p = 0.0002).

Full Text

Duke Authors

Cited Authors

  • Cantor, WJ; Kaplan, AL; Velianou, JL; Sketch, MH; Barsness, GW; Berger, PB; Ohman, EM

Published Date

  • February 15, 2001

Published In

Volume / Issue

  • 87 / 4

Start / End Page

  • 439 - A4

PubMed ID

  • 11179529

Pubmed Central ID

  • 11179529

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/s0002-9149(00)01398-9

Language

  • eng

Conference Location

  • United States