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Adiponectin is not altered with exercise training despite enhanced insulin action.

Publication ,  Journal Article
Hulver, MW; Zheng, D; Tanner, CJ; Houmard, JA; Kraus, WE; Slentz, CA; Sinha, MK; Pories, WJ; MacDonald, KG; Dohm, GL
Published in: Am J Physiol Endocrinol Metab
October 2002

Adiponectin is an adipocytokine that is hypothesized to be involved in the regulation of insulin action. The purpose of the present investigation was to determine whether plasma adiponectin is altered in conjunction with enhanced insulin action with exercise training. An insulin sensitivity index (S(I)) and fasting levels of glucose, insulin, and adiponectin were assessed before and after 6 mo of exercise training (4 days/wk for approximately 45 min at 65-80% peak O(2) consumption) with no loss of body mass (PRE, 91.9 +/- 3.8 kg vs. POST, 91.6 +/- 3.9 kg) or fat mass (PRE, 26.5 +/- 1.8 kg vs. POST, 26.7 +/- 2.2 kg). Insulin action significantly (P < 0.05) improved with exercise training (S(I) +98%); however, plasma adiponectin concentration did not change (PRE, 6.3 +/- 1.5 microg/ml vs. POST, 6.6 +/- 1.8 microg/ml). In contrast, in a separate group of subjects examined before and after weight loss, there was a substantial increase in adiponectin (+281%), which was accompanied by enhanced insulin action (S(I), +432%). These data suggest that adiponectin is not a contributory factor to the exercise-related improvements in insulin sensitivity.

Duke Scholars

Published In

Am J Physiol Endocrinol Metab

DOI

ISSN

0193-1849

Publication Date

October 2002

Volume

283

Issue

4

Start / End Page

E861 / E865

Location

United States

Related Subject Headings

  • Weight Loss
  • Proteins
  • Obesity
  • Middle Aged
  • Male
  • Intercellular Signaling Peptides and Proteins
  • Insulin
  • Humans
  • Gastric Bypass
  • Female
 

Citation

APA
Chicago
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MLA
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Hulver, M. W., Zheng, D., Tanner, C. J., Houmard, J. A., Kraus, W. E., Slentz, C. A., … Dohm, G. L. (2002). Adiponectin is not altered with exercise training despite enhanced insulin action. Am J Physiol Endocrinol Metab, 283(4), E861–E865. https://doi.org/10.1152/ajpendo.00150.2002
Hulver, Matthew W., Donghai Zheng, Charles J. Tanner, Joseph A. Houmard, William E. Kraus, Cris A. Slentz, Madhur K. Sinha, Walter J. Pories, Kenneth G. MacDonald, and G Lynis Dohm. “Adiponectin is not altered with exercise training despite enhanced insulin action.Am J Physiol Endocrinol Metab 283, no. 4 (October 2002): E861–65. https://doi.org/10.1152/ajpendo.00150.2002.
Hulver MW, Zheng D, Tanner CJ, Houmard JA, Kraus WE, Slentz CA, et al. Adiponectin is not altered with exercise training despite enhanced insulin action. Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E861–5.
Hulver, Matthew W., et al. “Adiponectin is not altered with exercise training despite enhanced insulin action.Am J Physiol Endocrinol Metab, vol. 283, no. 4, Oct. 2002, pp. E861–65. Pubmed, doi:10.1152/ajpendo.00150.2002.
Hulver MW, Zheng D, Tanner CJ, Houmard JA, Kraus WE, Slentz CA, Sinha MK, Pories WJ, MacDonald KG, Dohm GL. Adiponectin is not altered with exercise training despite enhanced insulin action. Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E861–E865.

Published In

Am J Physiol Endocrinol Metab

DOI

ISSN

0193-1849

Publication Date

October 2002

Volume

283

Issue

4

Start / End Page

E861 / E865

Location

United States

Related Subject Headings

  • Weight Loss
  • Proteins
  • Obesity
  • Middle Aged
  • Male
  • Intercellular Signaling Peptides and Proteins
  • Insulin
  • Humans
  • Gastric Bypass
  • Female