Regenerating functional myocardium: improved performance after skeletal myoblast transplantation.

Published

Journal Article

The adult heart lacks reserve cardiocytes and cannot regenerate. Therefore, a large acute myocardial infarction often develops into congestive heart failure. To attempt to prevent this progression, we transplanted skeletal myoblasts into cryoinfarcted myocardium of the same rabbits (autologous transfer), monitored cardiac function in vivo for two to six weeks and examined serial sections of the hearts by light and electron microscopy. Islands of different sizes comprising elongated, striated cells that retained characteristics of both skeletal and cardiac cells were found in the cryoinfarct. In rabbits in which myoblasts were incorporated, myocardial performance was improved. The ability to regenerate functioning muscle after autologous myoblast transplantation could have a important effect on patients after acute myocardial infarction.

Full Text

Duke Authors

Cited Authors

  • Taylor, DA; Atkins, BZ; Hungspreugs, P; Jones, TR; Reedy, MC; Hutcheson, KA; Glower, DD; Kraus, WE

Published Date

  • August 1998

Published In

Volume / Issue

  • 4 / 8

Start / End Page

  • 929 - 933

PubMed ID

  • 9701245

Pubmed Central ID

  • 9701245

Electronic International Standard Serial Number (EISSN)

  • 1546-170X

International Standard Serial Number (ISSN)

  • 1078-8956

Digital Object Identifier (DOI)

  • 10.1038/nm0898-929

Language

  • eng