Regenerating functional myocardium: improved performance after skeletal myoblast transplantation.
Journal Article (Journal Article)
The adult heart lacks reserve cardiocytes and cannot regenerate. Therefore, a large acute myocardial infarction often develops into congestive heart failure. To attempt to prevent this progression, we transplanted skeletal myoblasts into cryoinfarcted myocardium of the same rabbits (autologous transfer), monitored cardiac function in vivo for two to six weeks and examined serial sections of the hearts by light and electron microscopy. Islands of different sizes comprising elongated, striated cells that retained characteristics of both skeletal and cardiac cells were found in the cryoinfarct. In rabbits in which myoblasts were incorporated, myocardial performance was improved. The ability to regenerate functioning muscle after autologous myoblast transplantation could have a important effect on patients after acute myocardial infarction.
Full Text
Duke Authors
Cited Authors
- Taylor, DA; Atkins, BZ; Hungspreugs, P; Jones, TR; Reedy, MC; Hutcheson, KA; Glower, DD; Kraus, WE
Published Date
- August 1998
Published In
Volume / Issue
- 4 / 8
Start / End Page
- 929 - 933
PubMed ID
- 9701245
Pubmed Central ID
- 9701245
International Standard Serial Number (ISSN)
- 1078-8956
Digital Object Identifier (DOI)
- 10.1038/nm0898-929
Language
- eng
Conference Location
- United States