Diphenylhydantoin reduces the outward current of the action potential in Aplysia.

Journal Article (Journal Article)

Diphenylhydantoin (DPH) has been shown to prolong the repolarization phase of action potentials in Aplysia and to reduce the spike after hyperpolarization. We voltage-clamped somata of Aplysia giant neurons and measured the action potential currents to determine what alterations might be responsible for the prolonged repolarization and reduced undershoot. DPH did not affect the peak inward current; however, it did reversibly reduce the outward current at concentrations of 38 microM or greater. The data indicate that DPH reduced the voltage sensitive potassium conductance rather than the 'A' current or the calcium activated potassium conductance. These changes in outward current would explain the prolonged action potentials and reduced afterhypolarization seen with DPH in Aplysia.

Full Text

Duke Authors

Cited Authors

  • Lewis, DV

Published Date

  • February 23, 1981

Published In

Volume / Issue

  • 207 / 1

Start / End Page

  • 234 - 238

PubMed ID

  • 6258734

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(81)90700-9


  • eng

Conference Location

  • Netherlands