NADH fluorescence, [K+]0 and oxygen consumption in cat cerebral cortex during direct cortical stimulation.


Journal Article

NADH fluorescence, sagittal sinus blood flow and sinus hemoglobin saturation were monitored simultaneously during direct cortical stimulation of a wide area of the anterior and mid suprasylvian and marginal gyri. The area monitored flurorometrically was located within the area apparently drained by the sinus, so that the flurometric changes could be correlated with oxygen consumption changes calculated from the sinus flow and saturation values. The onset and peak values of calculated oxygen consumption and NADH fluorescence changes usually occurred within several seconds of one another and high, significant (r greater than 0.9 and P less than 0.01) correlations were found between the maximum changes in both parameters following stimulation. The relation of cortical [K+]0 changes to oxygen consumption changes was also explored; again the magnitude of [K+]0 changes and calculated oxygen consumption changes correlated well. The demonstrated agreement between fluorometric and direct (sinus cannulation) measurements of oxidative metabolism reinforces the interpretation of in situ cortical fluorescence changes as indicative of changes in oxygen consumption rate

Full Text

Duke Authors

Cited Authors

  • Lewis, DV; Schuette, WH

Published Date

  • July 16, 1976

Published In

Volume / Issue

  • 110 / 3

Start / End Page

  • 523 - 535

PubMed ID

  • 181114

Pubmed Central ID

  • 181114

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(76)90863-5


  • eng

Conference Location

  • Netherlands