Facilitation of the induction of long-term potentiation by GABAB receptors.

Journal Article (Journal Article)

Long-term potentiation (LTP), an in vitro model of learning, was induced in hippocampal slices by 5-hertz stimulation. During induction, gamma-aminobutyric acid A (GABAA) inhibition decreased, causing the N-methyl-D-aspartate receptor-mediated excitation to increase. 2-OH Saclofen, a GABAB receptor antagonist, prevented the reduction of inhibition, the increase of excitation, and the induction of LTP. Therefore, disinhibition caused by GABAB receptors is required for induction of LTP by 5-hertz stimulation. GABAB receptor modulation of synaptic plasticity occurs at frequencies in the range of the endogenous hippocampal theta rhythm, which has been shown to modulate LTP in vivo.

Full Text

Duke Authors

Cited Authors

  • Mott, DD; Lewis, DV

Published Date

  • June 21, 1991

Published In

Volume / Issue

  • 252 / 5013

Start / End Page

  • 1718 - 1720

PubMed ID

  • 1675489

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1675489


  • eng

Conference Location

  • United States