Facilitation of the induction of long-term potentiation by GABAB receptors.
Publication
, Journal Article
Mott, DD; Lewis, DV
Published in: Science
June 21, 1991
Long-term potentiation (LTP), an in vitro model of learning, was induced in hippocampal slices by 5-hertz stimulation. During induction, gamma-aminobutyric acid A (GABAA) inhibition decreased, causing the N-methyl-D-aspartate receptor-mediated excitation to increase. 2-OH Saclofen, a GABAB receptor antagonist, prevented the reduction of inhibition, the increase of excitation, and the induction of LTP. Therefore, disinhibition caused by GABAB receptors is required for induction of LTP by 5-hertz stimulation. GABAB receptor modulation of synaptic plasticity occurs at frequencies in the range of the endogenous hippocampal theta rhythm, which has been shown to modulate LTP in vivo.
Duke Scholars
Published In
Science
DOI
ISSN
0036-8075
Publication Date
June 21, 1991
Volume
252
Issue
5013
Start / End Page
1718 / 1720
Location
United States
Related Subject Headings
- Receptors, GABA-A
- Neuronal Plasticity
- Neural Inhibition
- Membrane Potentials
- Learning
- In Vitro Techniques
- Hippocampus
- General Science & Technology
- Evoked Potentials
- Electric Stimulation
Citation
APA
Chicago
ICMJE
MLA
NLM
Mott, D. D., & Lewis, D. V. (1991). Facilitation of the induction of long-term potentiation by GABAB receptors. Science, 252(5013), 1718–1720. https://doi.org/10.1126/science.1675489
Mott, D. D., and D. V. Lewis. “Facilitation of the induction of long-term potentiation by GABAB receptors.” Science 252, no. 5013 (June 21, 1991): 1718–20. https://doi.org/10.1126/science.1675489.
Mott DD, Lewis DV. Facilitation of the induction of long-term potentiation by GABAB receptors. Science. 1991 Jun 21;252(5013):1718–20.
Mott, D. D., and D. V. Lewis. “Facilitation of the induction of long-term potentiation by GABAB receptors.” Science, vol. 252, no. 5013, June 1991, pp. 1718–20. Pubmed, doi:10.1126/science.1675489.
Mott DD, Lewis DV. Facilitation of the induction of long-term potentiation by GABAB receptors. Science. 1991 Jun 21;252(5013):1718–1720.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
June 21, 1991
Volume
252
Issue
5013
Start / End Page
1718 / 1720
Location
United States
Related Subject Headings
- Receptors, GABA-A
- Neuronal Plasticity
- Neural Inhibition
- Membrane Potentials
- Learning
- In Vitro Techniques
- Hippocampus
- General Science & Technology
- Evoked Potentials
- Electric Stimulation