Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats.
Publication
, Journal Article
Morrisett, RA; Mott, DD; Lewis, DV; Wilson, WA; Swartzwelder, HS
Published in: Brain Res Dev Brain Res
November 1, 1990
This study describes the measurement of N-methyl-D-aspartate (NMDA)-mediated excitatory postsynaptic potentials (EPSPs) of the CA1 subregion of transverse hippocampal slices from immature and adult rats. Our methods permit extracellular measurement of NMDA-mediated depolarizations in the presence of magnesium (Mg2+) ions. In comparison to slices from adult rats (75-90 days old), NMDA EPSPs in hippocampus from immature rats (25-35 days old) were of significantly greater amplitude and were significantly less sensitive to magnesium. It is suggested that developmental plasticity may be related to changes in magnesium regulation of the NMDA channel complex.
Duke Scholars
Published In
Brain Res Dev Brain Res
DOI
ISSN
0165-3806
Publication Date
November 1, 1990
Volume
56
Issue
2
Start / End Page
257 / 262
Location
Netherlands
Related Subject Headings
- Synaptic Transmission
- Synapses
- Receptors, N-Methyl-D-Aspartate
- Rats, Inbred Strains
- Rats
- Quinoxalines
- Pyramidal Tracts
- Picrotoxin
- Neurology & Neurosurgery
- Male
Citation
APA
Chicago
ICMJE
MLA
NLM
Morrisett, R. A., Mott, D. D., Lewis, D. V., Wilson, W. A., & Swartzwelder, H. S. (1990). Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats. Brain Res Dev Brain Res, 56(2), 257–262. https://doi.org/10.1016/0165-3806(90)90090-l
Morrisett, R. A., D. D. Mott, D. V. Lewis, W. A. Wilson, and H. S. Swartzwelder. “Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats.” Brain Res Dev Brain Res 56, no. 2 (November 1, 1990): 257–62. https://doi.org/10.1016/0165-3806(90)90090-l.
Morrisett RA, Mott DD, Lewis DV, Wilson WA, Swartzwelder HS. Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats. Brain Res Dev Brain Res. 1990 Nov 1;56(2):257–62.
Morrisett, R. A., et al. “Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats.” Brain Res Dev Brain Res, vol. 56, no. 2, Nov. 1990, pp. 257–62. Pubmed, doi:10.1016/0165-3806(90)90090-l.
Morrisett RA, Mott DD, Lewis DV, Wilson WA, Swartzwelder HS. Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats. Brain Res Dev Brain Res. 1990 Nov 1;56(2):257–262.
Published In
Brain Res Dev Brain Res
DOI
ISSN
0165-3806
Publication Date
November 1, 1990
Volume
56
Issue
2
Start / End Page
257 / 262
Location
Netherlands
Related Subject Headings
- Synaptic Transmission
- Synapses
- Receptors, N-Methyl-D-Aspartate
- Rats, Inbred Strains
- Rats
- Quinoxalines
- Pyramidal Tracts
- Picrotoxin
- Neurology & Neurosurgery
- Male