Human G(alpha q): cDNA and tissue distribution.
Journal Article (Journal Article)
G(alpha q), a member of the Gq family of heterotrimeric G proteins, transduces signals from several G protein-coupled receptors that stimulate membrane phosphoinositide hydrolysis. In order to further define the role of G(alpha q) in the function of G protein-coupled receptors, we have cloned the cDNA encoding human G(alpha q) from a prostate cDNA library. Human G(alpha q) exhibits high homology with its mouse homolog - 94% similarity at the nucleotide level, and 99% similarity at the amino acid level. Northern hybridization data indicate high expression of G(alpha q) mRNA in organs of the human reproductive system including ovary, prostate, and testis.
- Chen, B; Leverette, RD; Schwinn, DA; Kwatra, MM
- June 11, 1996
Volume / Issue
- 1281 / 2
Start / End Page
- 125 - 128
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)