Human G(alpha q): cDNA and tissue distribution.

Journal Article (Journal Article)

G(alpha q), a member of the Gq family of heterotrimeric G proteins, transduces signals from several G protein-coupled receptors that stimulate membrane phosphoinositide hydrolysis. In order to further define the role of G(alpha q) in the function of G protein-coupled receptors, we have cloned the cDNA encoding human G(alpha q) from a prostate cDNA library. Human G(alpha q) exhibits high homology with its mouse homolog - 94% similarity at the nucleotide level, and 99% similarity at the amino acid level. Northern hybridization data indicate high expression of G(alpha q) mRNA in organs of the human reproductive system including ovary, prostate, and testis.

Full Text

Duke Authors

Cited Authors

  • Chen, B; Leverette, RD; Schwinn, DA; Kwatra, MM

Published Date

  • June 11, 1996

Published In

Volume / Issue

  • 1281 / 2

Start / End Page

  • 125 - 128

PubMed ID

  • 8664309

International Standard Serial Number (ISSN)

  • 0006-3002

Digital Object Identifier (DOI)

  • 10.1016/0005-2736(96)00039-9


  • eng

Conference Location

  • Netherlands