N6-phenyladenosines: pronounced effect of phenyl substituents on affinity for A2 adenosine receptors.

Journal Article (Journal Article)

A number of N6-phenyladenosines with various substitutions on the phenyl ring have been synthesized and tested for their affinities toward brain A1 and A2 adenosine receptors. Compounds with meta substituents, such as (m-hydroxy- and m-iodophenyl)adenosine, were found to have high A1 selectivity. Meta substitution caused a selective decrease in the affinity of these compounds for A2 receptors. The results suggest that, in contrast to what is commonly held, certain N6-substituents have pronounced effects on affinity for brain A2 adenosine receptors. Thus, brain A2 receptors may have a well-defined region that recognizes N6-substitutions.

Full Text

Duke Authors

Cited Authors

  • Kwatra, MM; Leung, E; Hosey, MM; Green, RD

Published Date

  • May 1987

Published In

Volume / Issue

  • 30 / 5

Start / End Page

  • 954 - 956

PubMed ID

  • 3572985

Pubmed Central ID

  • 3572985

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm00388a039


  • eng

Conference Location

  • United States