Acetylenics. 2. Synthesis and pharmacology of certain N,N-diakyl-3-phenylpropyn-2-amines. Some analogues with tryptamine-like behavioral effects in mice.

Journal Article (Journal Article)

A number of N,N-dialkyl-3-phenylpropyn-2-amines 7 have been prepared and tested for their biological action. Certain analogues show tryptamine-like behavior effects in mice. The tryptamine-like activity of these compounds appears to be controlled by their lipophilicity. These compounds show only weak inhibition of rat liver monoamine oxidase. Although these compounds exhibit tryptamine-like action, experiments seem to indicate that there is no interaction with the tryptamine receptors.

Full Text

Duke Authors

Cited Authors

  • Kwatra, MM; Simon, DZ; Salvador, RL; Cooper, PD

Published Date

  • March 1, 1978

Published In

Volume / Issue

  • 21 / 3

Start / End Page

  • 253 - 257

PubMed ID

  • 627999

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm00201a003


  • eng

Conference Location

  • United States