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Acetylenics. 2. Synthesis and pharmacology of certain N,N-diakyl-3-phenylpropyn-2-amines. Some analogues with tryptamine-like behavioral effects in mice.

Publication ,  Journal Article
Kwatra, MM; Simon, DZ; Salvador, RL; Cooper, PD
Published in: J Med Chem
March 1978

A number of N,N-dialkyl-3-phenylpropyn-2-amines 7 have been prepared and tested for their biological action. Certain analogues show tryptamine-like behavior effects in mice. The tryptamine-like activity of these compounds appears to be controlled by their lipophilicity. These compounds show only weak inhibition of rat liver monoamine oxidase. Although these compounds exhibit tryptamine-like action, experiments seem to indicate that there is no interaction with the tryptamine receptors.

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Published In

J Med Chem

DOI

ISSN

0022-2623

Publication Date

March 1978

Volume

21

Issue

3

Start / End Page

253 / 257

Location

United States

Related Subject Headings

  • Receptors, Serotonin
  • Rats
  • Motor Activity
  • Monoamine Oxidase Inhibitors
  • Mice
  • Medicinal & Biomolecular Chemistry
  • Male
  • Lethal Dose 50
  • In Vitro Techniques
  • Behavior, Animal
 

Citation

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Kwatra, M. M., Simon, D. Z., Salvador, R. L., & Cooper, P. D. (1978). Acetylenics. 2. Synthesis and pharmacology of certain N,N-diakyl-3-phenylpropyn-2-amines. Some analogues with tryptamine-like behavioral effects in mice. J Med Chem, 21(3), 253–257. https://doi.org/10.1021/jm00201a003
Kwatra, M. M., D. Z. Simon, R. L. Salvador, and P. D. Cooper. “Acetylenics. 2. Synthesis and pharmacology of certain N,N-diakyl-3-phenylpropyn-2-amines. Some analogues with tryptamine-like behavioral effects in mice.J Med Chem 21, no. 3 (March 1978): 253–57. https://doi.org/10.1021/jm00201a003.
Kwatra, M. M., et al. “Acetylenics. 2. Synthesis and pharmacology of certain N,N-diakyl-3-phenylpropyn-2-amines. Some analogues with tryptamine-like behavioral effects in mice.J Med Chem, vol. 21, no. 3, Mar. 1978, pp. 253–57. Pubmed, doi:10.1021/jm00201a003.
Journal cover image

Published In

J Med Chem

DOI

ISSN

0022-2623

Publication Date

March 1978

Volume

21

Issue

3

Start / End Page

253 / 257

Location

United States

Related Subject Headings

  • Receptors, Serotonin
  • Rats
  • Motor Activity
  • Monoamine Oxidase Inhibitors
  • Mice
  • Medicinal & Biomolecular Chemistry
  • Male
  • Lethal Dose 50
  • In Vitro Techniques
  • Behavior, Animal