Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent.
Journal Article (Journal Article)
When labeled using the Iodogen method, a chimeric antibody composed of the human IgG2 constant region and the variable regions of murine anti-tenascin 81C6 exhibited superior uptake in human glioma xenografts compared with its murine parent. In the current study, three paired-label experiments were performed in athymic mice with subcutaneous D-54 MG human glioma xenografts to evaluate further the properties of radioiodinated chimeric 81C6. These studies demonstrated that (a) the enhanced tumor uptake of chimeric 81C6 is specific; (b) when labeling was performed using N-succinimidyl 3-iodobenzoate, chimeric 81C6 again showed preferential accumulation in tumor compared with murine 81C6; and (c) the tumor uptake advantage observed previously with murine 81C6 for N-succinimidyl 3-iodobenzoate compared with Iodogen labeling did not occur with chimeric 81C6.
Full Text
Duke Authors
Cited Authors
- Zalutsky, MR; Archer, GE; Garg, PK; Batra, SK; Bigner, DD
Published Date
- May 1996
Published In
Volume / Issue
- 23 / 4
Start / End Page
- 449 - 458
PubMed ID
- 8832699
Pubmed Central ID
- 8832699
International Standard Serial Number (ISSN)
- 0969-8051
Digital Object Identifier (DOI)
- 10.1016/0969-8051(96)00021-2
Language
- eng
Conference Location
- United States