Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent.

Published

Journal Article

When labeled using the Iodogen method, a chimeric antibody composed of the human IgG2 constant region and the variable regions of murine anti-tenascin 81C6 exhibited superior uptake in human glioma xenografts compared with its murine parent. In the current study, three paired-label experiments were performed in athymic mice with subcutaneous D-54 MG human glioma xenografts to evaluate further the properties of radioiodinated chimeric 81C6. These studies demonstrated that (a) the enhanced tumor uptake of chimeric 81C6 is specific; (b) when labeling was performed using N-succinimidyl 3-iodobenzoate, chimeric 81C6 again showed preferential accumulation in tumor compared with murine 81C6; and (c) the tumor uptake advantage observed previously with murine 81C6 for N-succinimidyl 3-iodobenzoate compared with Iodogen labeling did not occur with chimeric 81C6.

Full Text

Duke Authors

Cited Authors

  • Zalutsky, MR; Archer, GE; Garg, PK; Batra, SK; Bigner, DD

Published Date

  • May 1996

Published In

Volume / Issue

  • 23 / 4

Start / End Page

  • 449 - 458

PubMed ID

  • 8832699

Pubmed Central ID

  • 8832699

International Standard Serial Number (ISSN)

  • 0969-8051

Language

  • eng

Conference Location

  • United States