Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft.

Journal Article

Based on previous work demonstrating the activity of cyclophosphamide and melphalan in a series of human medulloblastoma and rhabdomyosarcoma cell lines and transplantable xenografts, investigations were conducted to define the effects of combining cyclophosphamide or melphalan with VP-16. These studies demonstrated a synergistic interaction between cyclophosphamide and VP-16 and melphalan and VP-16 in the treatment of the human rhabdomyosarcoma cell line TE-671 growing in athymic mice. The combination of cyclophosphamide or melphalan with VP-16 may warrant consideration as a therapeutic strategy for solid tumors sensitive to bifunctional alkylating agents.

Full Text

Duke Authors

Cited Authors

  • Lilley, ER; Rosenberg, MC; Elion, GB; Colvin, OM; Bigner, DD; Friedman, HS

Published Date

  • January 15, 1990

Published In

Volume / Issue

  • 50 / 2

Start / End Page

  • 284 - 287

PubMed ID

  • 2295068

International Standard Serial Number (ISSN)

  • 0008-5472

Language

  • eng

Conference Location

  • United States