Effect of glutamate analogues on brain tumor cell lines.

Journal Article (Journal Article)

Glutamate analogues have been used in many different experimental approaches in neurobiology. A small number of these analogues have been classified as gliotoxic. We have examined the effect of seven glutamate analogues (five gliotoxic and two neurotoxic) on the growth and viability of four human glioma cell lines, one human medulloblastoma cell line, and one human sarcoma cell line. Aminoadipic acid and homocysteic acid predominantly affected the growth of two glioma cell lines in the presence of 4 mM glutamine. Phosphonobutyric acid predominantly affected the other two glioma cell lines and the medulloblastoma cell line in the presence of 4 mM glutamine. In medium containing no glutamine, all three analogues had marked effects on all the cell lines except the sarcoma cell line. These effects were dose dependent. We postulate that these results can in part be explained on the basis of metabolic compartmentalization.

Full Text

Duke Authors

Cited Authors

  • Campbell, GL; Bartel, R; Freidman, HS; Bigner, DD

Published Date

  • October 1985

Published In

Volume / Issue

  • 45 / 4

Start / End Page

  • 1186 - 1192

PubMed ID

  • 2863331

International Standard Serial Number (ISSN)

  • 0022-3042

Digital Object Identifier (DOI)

  • 10.1111/j.1471-4159.1985.tb05540.x


  • eng

Conference Location

  • England