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Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion.

Publication ,  Journal Article
Friedman, HS; Colvin, OM; Griffith, OW; Lippitz, B; Elion, GB; Schold, SC; Hilton, J; Bigner, DD
Published in: J Natl Cancer Inst
April 5, 1989

In previous studies we demonstrated that administration of buthionine sulfoximine (BSO) to athymic BALB/c mice bearing intracranial human glioma xenografts resulted in highly selective depletion of glutathione in neoplastic tissue with minimal effects on contralateral normal brain tissue. In the present study we treated athymic BALB/c mice bearing intracranial human glioma (D-54 MG) or medulloblastoma (TE-671) xenografts with melphalan alone or BSO followed by melphalan. Administration of BSO depleted intracellular glutathione to 7.5% of the control level. BSO plus melphalan resulted in a significant increase in median survival over that produced by melphalan alone: 45.3% versus 26.4% in TE-671 and 69% versus 27.6% in D-54 MG. These studies justify further efforts to modulate chemotherapeutic and radiotherapeutic interventions of primary malignant brain tumors by depletion of glutathione.

Duke Scholars

Published In

J Natl Cancer Inst

DOI

ISSN

0027-8874

Publication Date

April 5, 1989

Volume

81

Issue

7

Start / End Page

524 / 527

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice
  • Methionine Sulfoximine
  • Melphalan
  • Medulloblastoma
  • Male
  • Humans
  • Glutathione
 

Citation

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Friedman, H. S., Colvin, O. M., Griffith, O. W., Lippitz, B., Elion, G. B., Schold, S. C., … Bigner, D. D. (1989). Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion. J Natl Cancer Inst, 81(7), 524–527. https://doi.org/10.1093/jnci/81.7.524
Friedman, H. S., O. M. Colvin, O. W. Griffith, B. Lippitz, G. B. Elion, S. C. Schold, J. Hilton, and D. D. Bigner. “Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion.J Natl Cancer Inst 81, no. 7 (April 5, 1989): 524–27. https://doi.org/10.1093/jnci/81.7.524.
Friedman HS, Colvin OM, Griffith OW, Lippitz B, Elion GB, Schold SC, et al. Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion. J Natl Cancer Inst. 1989 Apr 5;81(7):524–7.
Friedman, H. S., et al. “Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion.J Natl Cancer Inst, vol. 81, no. 7, Apr. 1989, pp. 524–27. Pubmed, doi:10.1093/jnci/81.7.524.
Friedman HS, Colvin OM, Griffith OW, Lippitz B, Elion GB, Schold SC, Hilton J, Bigner DD. Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion. J Natl Cancer Inst. 1989 Apr 5;81(7):524–527.
Journal cover image

Published In

J Natl Cancer Inst

DOI

ISSN

0027-8874

Publication Date

April 5, 1989

Volume

81

Issue

7

Start / End Page

524 / 527

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice
  • Methionine Sulfoximine
  • Melphalan
  • Medulloblastoma
  • Male
  • Humans
  • Glutathione