Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion.

Published

Journal Article

In previous studies we demonstrated that administration of buthionine sulfoximine (BSO) to athymic BALB/c mice bearing intracranial human glioma xenografts resulted in highly selective depletion of glutathione in neoplastic tissue with minimal effects on contralateral normal brain tissue. In the present study we treated athymic BALB/c mice bearing intracranial human glioma (D-54 MG) or medulloblastoma (TE-671) xenografts with melphalan alone or BSO followed by melphalan. Administration of BSO depleted intracellular glutathione to 7.5% of the control level. BSO plus melphalan resulted in a significant increase in median survival over that produced by melphalan alone: 45.3% versus 26.4% in TE-671 and 69% versus 27.6% in D-54 MG. These studies justify further efforts to modulate chemotherapeutic and radiotherapeutic interventions of primary malignant brain tumors by depletion of glutathione.

Full Text

Duke Authors

Cited Authors

  • Friedman, HS; Colvin, OM; Griffith, OW; Lippitz, B; Elion, GB; Schold, SC; Hilton, J; Bigner, DD

Published Date

  • April 5, 1989

Published In

Volume / Issue

  • 81 / 7

Start / End Page

  • 524 - 527

PubMed ID

  • 2921776

Pubmed Central ID

  • 2921776

International Standard Serial Number (ISSN)

  • 0027-8874

Digital Object Identifier (DOI)

  • 10.1093/jnci/81.7.524

Language

  • eng

Conference Location

  • United States