Deletion of p16 and p15 genes in brain tumors.

Journal Article

We have used molecular genetic methods to examine the status of cell cycle-inhibitory genes in human brain tumors. We found that p16 and a neighboring gene, p15, were often homozygously deleted in glioblastoma multiformes but not in medulloblastomas or ependymomas. The deletions occurred in both primary tumors and their derived xenografts, but no intragenic mutations in either of the two genes were found. The p15 gene was expressed in a more widespread pattern in normal tissues than p16, but the products of both genes had similar capacities to bind to cyclin D-dependent kinases 4 and 6. These data suggest that the target of deletion in glioblastoma multiforme includes both p15 and p16 genes. The reason that homozygous deletions, rather than intragenic mutations, are so common in these tumors may be that deletion is a more efficient mechanism for simultaneous inactivation of both genes.

Full Text

Duke Authors

Cited Authors

  • Jen, J; Harper, JW; Bigner, SH; Bigner, DD; Papadopoulos, N; Markowitz, S; Willson, JK; Kinzler, KW; Vogelstein, B

Published Date

  • December 15, 1994

Published In

Volume / Issue

  • 54 / 24

Start / End Page

  • 6353 - 6358

PubMed ID

  • 7987828

International Standard Serial Number (ISSN)

  • 0008-5472

Language

  • eng

Conference Location

  • United States