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Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors.

Publication ,  Journal Article
Hanley, ML; Elion, GB; Colvin, OM; Modrich, PL; Keir, S; Adams, DJ; Bigner, DD; Friedman, HS
Published in: Cancer Chemother Pharmacol
1998

PURPOSE: The activity of vinorellbine, a new semisynthetic vinca alkaloid, was evaluated against a battery of human tumor xenografts derived from adult and pediatric CNS malignancies. METHODS: Tumors included adult high-grade gliomas (D-54 MG, D-245 MG), childhood high-grade gliomas (D-212 MG, D-456 MG), medulloblastomas (D-341 MED, D-487 MED), ependymomas (D-612 EP, D-528 EP), and a mismatch repair-deficient procarbazine-resistant glioma [D-245 MG (PR)]. Tumors were grown subcutaneously in athymic nude mice and vinorelbine was administered at a dose of 11 mg/kg on days 1, 5, and 9. Additionally, vinorelbine was also administered in combination with BCNU against D-54 MG. RESULTS: Vinorelbine produced statistically significant growth delays in D-456 MG, D-245 MG, and D-245 MG (PR). No statistically significant growth delays were observed in D-54 MG, D-487 MED, D-212 MG, D-528 EP, D-341 MED or D-612 EP. The antitumor effects of the vinorelbine/BCNU combination were additive. Growth delays observed in the procarbazine-resistant line [D-245 MG (PR)] were greater than twofold the delays seen in the parent line (D-245 MG). Vincristine was equally potent against D-245 MG and D-245 MG (PR). Taxol demonstrated little activity against D-245 MG but produced 32- and 18-day growth delays in D245 MG (PR). CONCLUSIONS: These studies indicate that vinorelbine possesses antitumor activity against several glioma tumor xenografts with marked activity in a mismatch repair deficient-tumor.

Duke Scholars

Published In

Cancer Chemother Pharmacol

DOI

ISSN

0344-5704

Publication Date

1998

Volume

42

Issue

6

Start / End Page

479 / 482

Location

Germany

Related Subject Headings

  • Vinorelbine
  • Vinblastine
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Mice, Inbred BALB C
  • Mice
  • Humans
  • Glioma
  • Female
  • Child
 

Citation

APA
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MLA
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Hanley, M. L., Elion, G. B., Colvin, O. M., Modrich, P. L., Keir, S., Adams, D. J., … Friedman, H. S. (1998). Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors. Cancer Chemother Pharmacol, 42(6), 479–482. https://doi.org/10.1007/s002800050848
Hanley, M. L., G. B. Elion, O. M. Colvin, P. L. Modrich, S. Keir, D. J. Adams, D. D. Bigner, and H. S. Friedman. “Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors.Cancer Chemother Pharmacol 42, no. 6 (1998): 479–82. https://doi.org/10.1007/s002800050848.
Hanley ML, Elion GB, Colvin OM, Modrich PL, Keir S, Adams DJ, et al. Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors. Cancer Chemother Pharmacol. 1998;42(6):479–82.
Hanley, M. L., et al. “Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors.Cancer Chemother Pharmacol, vol. 42, no. 6, 1998, pp. 479–82. Pubmed, doi:10.1007/s002800050848.
Hanley ML, Elion GB, Colvin OM, Modrich PL, Keir S, Adams DJ, Bigner DD, Friedman HS. Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors. Cancer Chemother Pharmacol. 1998;42(6):479–482.
Journal cover image

Published In

Cancer Chemother Pharmacol

DOI

ISSN

0344-5704

Publication Date

1998

Volume

42

Issue

6

Start / End Page

479 / 482

Location

Germany

Related Subject Headings

  • Vinorelbine
  • Vinblastine
  • Oncology & Carcinogenesis
  • Neoplasm Transplantation
  • Mice, Inbred BALB C
  • Mice
  • Humans
  • Glioma
  • Female
  • Child