The role of the subependymal plate in glial tumorigenesis.


Journal Article

We have studied the sequential morphological events of glial tumorigenesis in neonatal dogs, using high titer subgroup C Bratislava-77 Avian Sarcoma Virus, given as 0.01 ml by intraventricular inoculation. The cells of the subependymal plate are those which seem to form the gliomas; cytoplasmic alterations are evident within 24 h after inoculation and microfoci of gliomas, contiguous with the subependymal plate of the lateral ventricles, are visible within 7 days. Independent tumors are present by the 10th post-inoculation day. These studies support the hypothesis of Globus and Kuhlenbeck, which implicates the cells of the subependymal palte in glial tumorigenesis.

Full Text

Duke Authors

Cited Authors

  • Vick, NA; Lin, MJ; Bigner, DD

Published Date

  • September 26, 1977

Published In

Volume / Issue

  • 40 / 1

Start / End Page

  • 63 - 71

PubMed ID

  • 199034

Pubmed Central ID

  • 199034

International Standard Serial Number (ISSN)

  • 0001-6322

Digital Object Identifier (DOI)

  • 10.1007/BF00688574


  • eng

Conference Location

  • Germany