A controlled study of efficacy of interstitial or external irradiation in a virus-induced brain-tumor model in rats.
In a controlled study of interstitial radiotherapy in the avian sarcoma virus (ASV)-induced glioma model in rats, prolongation of survival was demonstrated (p = 0.08 in Experiment 1 and p = 0.03 in Experiment 2) following mean dosages of 7582 to 9902 cGy 125I, when compared to nontreatment or to control studies with implantation of nonradioactive seeds. More significant (p = 0.02) prolongation of survival was demonstrated following external beam whole-head radiotherapy with nine fractions of 333 cGy, three times weekly over 3 weeks (total dose 3000 cGy). Survival was more prolonged when whole-head radiotherapy was begun 35 days following virus inoculation rather than at 71 days, probably reflecting a greater efficacy with smaller tumor targets.
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Related Subject Headings
- Survival Analysis
- Rats, Inbred F344
- Rats
- Neurology & Neurosurgery
- Male
- Female
- Evaluation Studies as Topic
- Brain Neoplasms
- Brachytherapy
- Avian Sarcoma Viruses
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Survival Analysis
- Rats, Inbred F344
- Rats
- Neurology & Neurosurgery
- Male
- Female
- Evaluation Studies as Topic
- Brain Neoplasms
- Brachytherapy
- Avian Sarcoma Viruses