A controlled study of efficacy of interstitial or external irradiation in a virus-induced brain-tumor model in rats.


Journal Article

In a controlled study of interstitial radiotherapy in the avian sarcoma virus (ASV)-induced glioma model in rats, prolongation of survival was demonstrated (p = 0.08 in Experiment 1 and p = 0.03 in Experiment 2) following mean dosages of 7582 to 9902 cGy 125I, when compared to nontreatment or to control studies with implantation of nonradioactive seeds. More significant (p = 0.02) prolongation of survival was demonstrated following external beam whole-head radiotherapy with nine fractions of 333 cGy, three times weekly over 3 weeks (total dose 3000 cGy). Survival was more prolonged when whole-head radiotherapy was begun 35 days following virus inoculation rather than at 71 days, probably reflecting a greater efficacy with smaller tumor targets.

Full Text

Duke Authors

Cited Authors

  • el-Hennawi, Y; Gillespie, GY; Mahaley, MS; Varia, MA; Bigner, DD; Stanton, C

Published Date

  • December 1989

Published In

Volume / Issue

  • 71 / 6

Start / End Page

  • 898 - 902

PubMed ID

  • 2555463

Pubmed Central ID

  • 2555463

International Standard Serial Number (ISSN)

  • 0022-3085

Digital Object Identifier (DOI)

  • 10.3171/jns.1989.71.6.0898


  • eng

Conference Location

  • United States