Therapeutic profile of the human glioma line D-54 MG in athymic mice.


Journal Article

We treated D-54 MG, an extensively characterized human glioma tumor line, in athymic mice with each of 20 antineoplastic drugs and two radiation doses. PCNU, melphalan, cyclophosphamide, and fludarabine were highly active against sc tumors. A single radiation dose of 2500 cGy produced a growth delay (T-C) of 22.0 days and four of seven tumor regressions (TRs), whereas 1500 cGy produced a T-C of 13.2 days and two of 10 TRs. Several other drugs produced smaller T-Cs and fewer TRs. With this model we can make quantitative determinations of the sensitivities of a human glioma line, permitting detailed studies of drug mechanisms.

Full Text

Duke Authors

Cited Authors

  • Schold, SC; Friedman, HS; Bigner, DD

Published Date

  • September 1987

Published In

Volume / Issue

  • 71 / 9

Start / End Page

  • 849 - 850

PubMed ID

  • 3621219

Pubmed Central ID

  • 3621219

International Standard Serial Number (ISSN)

  • 0361-5960


  • eng

Conference Location

  • United States