Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate.
Journal Article (Journal Article)
A paired-label study was performed in athymic mice bearing subcutaneous D-54 MG human glioma xenografts to compare the localization of human/mouse anti-tenascin chimeric antibody 81C6 labeled by reaction with N-succinimidyl 3-[211At]astatobenzoate and N-succinimidyl 3-[131I]iodobenzoate. Over the 48-h observation period, the distribution of 211At- and 131I-labeled antibody were quite similar in tumor and normal tissues except stomach. These data were used to calculate human radiation doses for both intravenously and intrathecal administered 211At-labeled chimeric 81C6 using a quality factor of 5 for alpha-emissions.
Full Text
Duke Authors
Cited Authors
- Zalutsky, MR; Stabin, MG; Larsen, RH; Bigner, DD
Published Date
- April 1997
Published In
Volume / Issue
- 24 / 3
Start / End Page
- 255 - 261
PubMed ID
- 9228660
International Standard Serial Number (ISSN)
- 0969-8051
Digital Object Identifier (DOI)
- 10.1016/s0969-8051(97)00060-7
Language
- eng
Conference Location
- United States