Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate.

Journal Article (Journal Article)

A paired-label study was performed in athymic mice bearing subcutaneous D-54 MG human glioma xenografts to compare the localization of human/mouse anti-tenascin chimeric antibody 81C6 labeled by reaction with N-succinimidyl 3-[211At]astatobenzoate and N-succinimidyl 3-[131I]iodobenzoate. Over the 48-h observation period, the distribution of 211At- and 131I-labeled antibody were quite similar in tumor and normal tissues except stomach. These data were used to calculate human radiation doses for both intravenously and intrathecal administered 211At-labeled chimeric 81C6 using a quality factor of 5 for alpha-emissions.

Full Text

Duke Authors

Cited Authors

  • Zalutsky, MR; Stabin, MG; Larsen, RH; Bigner, DD

Published Date

  • April 1997

Published In

Volume / Issue

  • 24 / 3

Start / End Page

  • 255 - 261

PubMed ID

  • 9228660

International Standard Serial Number (ISSN)

  • 0969-8051

Digital Object Identifier (DOI)

  • 10.1016/s0969-8051(97)00060-7


  • eng

Conference Location

  • United States