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Experimental gliomas: an autoradiographic study of the endothelial component.

Publication ,  Journal Article
Groothuis, DR; Fischer, JM; Vick, NA; Bigner, DD
Published in: Neurology
March 1980

Autochthonous gliomas were induced in rats by intracerebral inoculation of avian of avian sarcoma virus and studied by 3H-thymidine autoradiography. Parenchymal glial tumor cells had a 3H-labeling index (LI) of 3.0 to 13.6%. Endothelial cells in tumor blood vessels had an LI of 2.6 to 34.3%, independent of and in most instances higher than the LI of the glial tumor. Endothelial cells of normal blood vessels had an average LI of 0.3%. This study documents the high proliferative rate of the endothelial cells in anaplastic experimental gliomas, and emphasizes the necessity for seeking direct, incontrovertible evidence to determine whether or not the rapidly proliferating endothelial cells are malignant.

Duke Scholars

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

March 1980

Volume

30

Issue

3

Start / End Page

297 / 301

Location

United States

Related Subject Headings

  • Sarcoma, Avian
  • Rats, Inbred F344
  • Rats
  • Neurology & Neurosurgery
  • Glioma
  • Endothelium
  • Cell Transformation, Neoplastic
  • Capillaries
  • Brain Neoplasms
  • Avian Sarcoma Viruses
 

Citation

APA
Chicago
ICMJE
MLA
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Groothuis, D. R., Fischer, J. M., Vick, N. A., & Bigner, D. D. (1980). Experimental gliomas: an autoradiographic study of the endothelial component. Neurology, 30(3), 297–301. https://doi.org/10.1212/wnl.30.3.297
Groothuis, D. R., J. M. Fischer, N. A. Vick, and D. D. Bigner. “Experimental gliomas: an autoradiographic study of the endothelial component.Neurology 30, no. 3 (March 1980): 297–301. https://doi.org/10.1212/wnl.30.3.297.
Groothuis DR, Fischer JM, Vick NA, Bigner DD. Experimental gliomas: an autoradiographic study of the endothelial component. Neurology. 1980 Mar;30(3):297–301.
Groothuis, D. R., et al. “Experimental gliomas: an autoradiographic study of the endothelial component.Neurology, vol. 30, no. 3, Mar. 1980, pp. 297–301. Pubmed, doi:10.1212/wnl.30.3.297.
Groothuis DR, Fischer JM, Vick NA, Bigner DD. Experimental gliomas: an autoradiographic study of the endothelial component. Neurology. 1980 Mar;30(3):297–301.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

March 1980

Volume

30

Issue

3

Start / End Page

297 / 301

Location

United States

Related Subject Headings

  • Sarcoma, Avian
  • Rats, Inbred F344
  • Rats
  • Neurology & Neurosurgery
  • Glioma
  • Endothelium
  • Cell Transformation, Neoplastic
  • Capillaries
  • Brain Neoplasms
  • Avian Sarcoma Viruses