Experimental gliomas: an autoradiographic study of the endothelial component.

Journal Article (Journal Article)

Autochthonous gliomas were induced in rats by intracerebral inoculation of avian of avian sarcoma virus and studied by 3H-thymidine autoradiography. Parenchymal glial tumor cells had a 3H-labeling index (LI) of 3.0 to 13.6%. Endothelial cells in tumor blood vessels had an LI of 2.6 to 34.3%, independent of and in most instances higher than the LI of the glial tumor. Endothelial cells of normal blood vessels had an average LI of 0.3%. This study documents the high proliferative rate of the endothelial cells in anaplastic experimental gliomas, and emphasizes the necessity for seeking direct, incontrovertible evidence to determine whether or not the rapidly proliferating endothelial cells are malignant.

Full Text

Duke Authors

Cited Authors

  • Groothuis, DR; Fischer, JM; Vick, NA; Bigner, DD

Published Date

  • March 1, 1980

Published In

Volume / Issue

  • 30 / 3

Start / End Page

  • 297 - 301

PubMed ID

  • 6244516

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.30.3.297


  • eng

Conference Location

  • United States