Experimental gliomas: an autoradiographic study of the endothelial component.
Publication
, Journal Article
Groothuis, DR; Fischer, JM; Vick, NA; Bigner, DD
Published in: Neurology
March 1980
Autochthonous gliomas were induced in rats by intracerebral inoculation of avian of avian sarcoma virus and studied by 3H-thymidine autoradiography. Parenchymal glial tumor cells had a 3H-labeling index (LI) of 3.0 to 13.6%. Endothelial cells in tumor blood vessels had an LI of 2.6 to 34.3%, independent of and in most instances higher than the LI of the glial tumor. Endothelial cells of normal blood vessels had an average LI of 0.3%. This study documents the high proliferative rate of the endothelial cells in anaplastic experimental gliomas, and emphasizes the necessity for seeking direct, incontrovertible evidence to determine whether or not the rapidly proliferating endothelial cells are malignant.
Duke Scholars
Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
March 1980
Volume
30
Issue
3
Start / End Page
297 / 301
Location
United States
Related Subject Headings
- Sarcoma, Avian
- Rats, Inbred F344
- Rats
- Neurology & Neurosurgery
- Glioma
- Endothelium
- Cell Transformation, Neoplastic
- Capillaries
- Brain Neoplasms
- Avian Sarcoma Viruses
Citation
APA
Chicago
ICMJE
MLA
NLM
Groothuis, D. R., Fischer, J. M., Vick, N. A., & Bigner, D. D. (1980). Experimental gliomas: an autoradiographic study of the endothelial component. Neurology, 30(3), 297–301. https://doi.org/10.1212/wnl.30.3.297
Groothuis, D. R., J. M. Fischer, N. A. Vick, and D. D. Bigner. “Experimental gliomas: an autoradiographic study of the endothelial component.” Neurology 30, no. 3 (March 1980): 297–301. https://doi.org/10.1212/wnl.30.3.297.
Groothuis DR, Fischer JM, Vick NA, Bigner DD. Experimental gliomas: an autoradiographic study of the endothelial component. Neurology. 1980 Mar;30(3):297–301.
Groothuis, D. R., et al. “Experimental gliomas: an autoradiographic study of the endothelial component.” Neurology, vol. 30, no. 3, Mar. 1980, pp. 297–301. Pubmed, doi:10.1212/wnl.30.3.297.
Groothuis DR, Fischer JM, Vick NA, Bigner DD. Experimental gliomas: an autoradiographic study of the endothelial component. Neurology. 1980 Mar;30(3):297–301.
Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
March 1980
Volume
30
Issue
3
Start / End Page
297 / 301
Location
United States
Related Subject Headings
- Sarcoma, Avian
- Rats, Inbred F344
- Rats
- Neurology & Neurosurgery
- Glioma
- Endothelium
- Cell Transformation, Neoplastic
- Capillaries
- Brain Neoplasms
- Avian Sarcoma Viruses