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Identification of an amplified, highly expressed gene in a human glioma.

Publication ,  Journal Article
Kinzler, KW; Bigner, SH; Bigner, DD; Trent, JM; Law, ML; O'Brien, SJ; Wong, AJ; Vogelstein, B
Published in: Science
April 3, 1987

A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

April 3, 1987

Volume

236

Issue

4797

Start / End Page

70 / 73

Location

United States

Related Subject Headings

  • RNA, Neoplasm
  • RNA, Messenger
  • Humans
  • Glioma
  • General Science & Technology
  • Gene Expression Regulation
  • Gene Amplification
  • DNA, Neoplasm
  • Cloning, Molecular
  • Chromosomes, Human, Pair 12
 

Citation

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Kinzler, K. W., Bigner, S. H., Bigner, D. D., Trent, J. M., Law, M. L., O’Brien, S. J., … Vogelstein, B. (1987). Identification of an amplified, highly expressed gene in a human glioma. Science, 236(4797), 70–73. https://doi.org/10.1126/science.3563490
Kinzler, K. W., S. H. Bigner, D. D. Bigner, J. M. Trent, M. L. Law, S. J. O’Brien, A. J. Wong, and B. Vogelstein. “Identification of an amplified, highly expressed gene in a human glioma.Science 236, no. 4797 (April 3, 1987): 70–73. https://doi.org/10.1126/science.3563490.
Kinzler KW, Bigner SH, Bigner DD, Trent JM, Law ML, O’Brien SJ, et al. Identification of an amplified, highly expressed gene in a human glioma. Science. 1987 Apr 3;236(4797):70–3.
Kinzler, K. W., et al. “Identification of an amplified, highly expressed gene in a human glioma.Science, vol. 236, no. 4797, Apr. 1987, pp. 70–73. Pubmed, doi:10.1126/science.3563490.
Kinzler KW, Bigner SH, Bigner DD, Trent JM, Law ML, O’Brien SJ, Wong AJ, Vogelstein B. Identification of an amplified, highly expressed gene in a human glioma. Science. 1987 Apr 3;236(4797):70–73.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

April 3, 1987

Volume

236

Issue

4797

Start / End Page

70 / 73

Location

United States

Related Subject Headings

  • RNA, Neoplasm
  • RNA, Messenger
  • Humans
  • Glioma
  • General Science & Technology
  • Gene Expression Regulation
  • Gene Amplification
  • DNA, Neoplasm
  • Cloning, Molecular
  • Chromosomes, Human, Pair 12