Identification of an amplified, highly expressed gene in a human glioma.

Journal Article (Journal Article)

A gene, termed gli, was identified that is amplified more than 50-fold in a malignant glioma. The gene is expressed at high levels in the original tumor and its derived cell line and is located at chromosome 12 position (q13 to q14.3). The gli gene is a member of a select group of cellular genes that are genetically altered in primary human tumors.

Full Text

Duke Authors

Cited Authors

  • Kinzler, KW; Bigner, SH; Bigner, DD; Trent, JM; Law, ML; O'Brien, SJ; Wong, AJ; Vogelstein, B

Published Date

  • April 3, 1987

Published In

Volume / Issue

  • 236 / 4797

Start / End Page

  • 70 - 73

PubMed ID

  • 3563490

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.3563490


  • eng

Conference Location

  • United States