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Circulating glycoconjugates in CSF of meningioma patients.

Publication ,  Journal Article
Davidsson, P; Fredman, P; von Holst, H; Wikstrand, CJ; He, X; Bigner, DD; Svennerholm, L
Published in: Acta Neurol Scand
September 1990

This study investigated whether tumor-associated gangliosides or glycoproteins may be markers for meningiomas in CSF. The concentrations of a number of gangliosides and sulphatide were determined with specific monoclonal antibodies and cholera toxin B-subunit in a thin-layer chromatography overlay technique. As compared to a reference group of 10 individuals (mean age 50 +/- 14 years), the CSF samples from 7 meningioma patients (mean age 55 +/- 12 years) were found to contain significantly increased concentrations of ganglioside GD3 [II3(NeuAc)2-LacCer], one of the major gangliosides in meningioma tissue specimens. Sulphatide was significantly increased in 6 of 7 patients. Tumor-associated glycoproteins detected by the lectin Ricinus communis 1 in meningioma tissue specimens, but not in normal human brain tissue, were also found in the CSF of the meningioma patients. An early diagnosis of meningiomas might be achieved by the combined assay in CSF of ganglioside GD3 and glycoproteins with Ricinus communis lectin.

Duke Scholars

Published In

Acta Neurol Scand

DOI

ISSN

0001-6314

Publication Date

September 1990

Volume

82

Issue

3

Start / End Page

203 / 208

Location

Denmark

Related Subject Headings

  • Sulfoglycosphingolipids
  • Neurology & Neurosurgery
  • Meningioma
  • Meningeal Neoplasms
  • Humans
  • Glycoproteins
  • Glycolipids
  • Glycoconjugates
  • Gangliosides
  • Biomarkers, Tumor
 

Citation

APA
Chicago
ICMJE
MLA
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Davidsson, P., Fredman, P., von Holst, H., Wikstrand, C. J., He, X., Bigner, D. D., & Svennerholm, L. (1990). Circulating glycoconjugates in CSF of meningioma patients. Acta Neurol Scand, 82(3), 203–208. https://doi.org/10.1111/j.1600-0404.1990.tb04489.x
Davidsson, P., P. Fredman, H. von Holst, C. J. Wikstrand, X. He, D. D. Bigner, and L. Svennerholm. “Circulating glycoconjugates in CSF of meningioma patients.Acta Neurol Scand 82, no. 3 (September 1990): 203–8. https://doi.org/10.1111/j.1600-0404.1990.tb04489.x.
Davidsson P, Fredman P, von Holst H, Wikstrand CJ, He X, Bigner DD, et al. Circulating glycoconjugates in CSF of meningioma patients. Acta Neurol Scand. 1990 Sep;82(3):203–8.
Davidsson, P., et al. “Circulating glycoconjugates in CSF of meningioma patients.Acta Neurol Scand, vol. 82, no. 3, Sept. 1990, pp. 203–08. Pubmed, doi:10.1111/j.1600-0404.1990.tb04489.x.
Davidsson P, Fredman P, von Holst H, Wikstrand CJ, He X, Bigner DD, Svennerholm L. Circulating glycoconjugates in CSF of meningioma patients. Acta Neurol Scand. 1990 Sep;82(3):203–208.
Journal cover image

Published In

Acta Neurol Scand

DOI

ISSN

0001-6314

Publication Date

September 1990

Volume

82

Issue

3

Start / End Page

203 / 208

Location

Denmark

Related Subject Headings

  • Sulfoglycosphingolipids
  • Neurology & Neurosurgery
  • Meningioma
  • Meningeal Neoplasms
  • Humans
  • Glycoproteins
  • Glycolipids
  • Glycoconjugates
  • Gangliosides
  • Biomarkers, Tumor