Determination of gangliosides in six human primary medulloblastomas.

Journal Article (Journal Article)

The ganglioside composition of six human medulloblastomas was analyzed. The characterization was performed by thin-layer chromatography, sialidase hydrolysis, and immunological staining with a panel of characterized antiganglioside monoclonal antibodies. The total ganglioside content ranged from 60 to 1,130 nmol of ganglioside sialic acid/g wet weight. Neuronal gangliosides (gangliotetraose series) were found in varying amounts in all medulloblastomas. Gangliosides of the neolactotetraose series (3'-LM1 and LD1) were present in all specimens, and the lactotetraose series ganglioside 3'-isoLM1 was found in all cases showing astrocytic differentiation. This supports our previous findings that 3'-isoLM1 is a marker for proliferating astroglial cells.

Full Text

Duke Authors

Cited Authors

  • Gottfries, J; Fredman, P; Månsson, JE; Collins, VP; von Holst, H; Armstrong, DD; Percy, AK; Wikstrand, CJ; Bigner, DD; Svennerholm, L

Published Date

  • October 1990

Published In

Volume / Issue

  • 55 / 4

Start / End Page

  • 1322 - 1326

PubMed ID

  • 2398361

International Standard Serial Number (ISSN)

  • 0022-3042

Digital Object Identifier (DOI)

  • 10.1111/j.1471-4159.1990.tb03142.x


  • eng

Conference Location

  • England