Heterotransplantation of human craniopharyngiomas in athymic "nude" mice.


Journal Article

Surgical biopsies from 2 human craniopharyngiomas were transplanted subcutaneously into 6 athymic "nude" mice. Morphologically characteristic craniopharyngiomas grew in 5 of these animals. In 4 animals growth was sufficient to allow transplantation into a second generation of animals. In all, 11 craniopharyngiomas were present at autopsy in the 14 animals into which the tumors had been transplanted. The tumors that grew in the animals had the same adamantinomatous architecture, epithelial nests, and keratinized nodules that were present in the original surgical sample and that are characteristic of human craniopharyngiomas. It may be possible to study growth characteristics and therapeutic sensitivities of human craniopharygniomas growing in "nude" mice.

Full Text

Duke Authors

Cited Authors

  • Bullard, DE; Bigner, DD

Published Date

  • April 1, 1979

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 308 - 314

PubMed ID

  • 450229

Pubmed Central ID

  • 450229

International Standard Serial Number (ISSN)

  • 0148-396X

Digital Object Identifier (DOI)

  • 10.1227/00006123-197904000-00006


  • eng

Conference Location

  • United States