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Heterotransplantation of human craniopharyngiomas in athymic "nude" mice.

Publication ,  Journal Article
Bullard, DE; Bigner, DD
Published in: Neurosurgery
April 1979

Surgical biopsies from 2 human craniopharyngiomas were transplanted subcutaneously into 6 athymic "nude" mice. Morphologically characteristic craniopharyngiomas grew in 5 of these animals. In 4 animals growth was sufficient to allow transplantation into a second generation of animals. In all, 11 craniopharyngiomas were present at autopsy in the 14 animals into which the tumors had been transplanted. The tumors that grew in the animals had the same adamantinomatous architecture, epithelial nests, and keratinized nodules that were present in the original surgical sample and that are characteristic of human craniopharyngiomas. It may be possible to study growth characteristics and therapeutic sensitivities of human craniopharygniomas growing in "nude" mice.

Duke Scholars

Published In

Neurosurgery

DOI

ISSN

0148-396X

Publication Date

April 1979

Volume

4

Issue

4

Start / End Page

308 / 314

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Neurology & Neurosurgery
  • Neoplasm Transplantation
  • Middle Aged
  • Mice, Nude
  • Mice
  • Male
  • Humans
  • Female
  • Craniopharyngioma
 

Citation

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Bullard, D. E., & Bigner, D. D. (1979). Heterotransplantation of human craniopharyngiomas in athymic "nude" mice. Neurosurgery, 4(4), 308–314. https://doi.org/10.1227/00006123-197904000-00006
Bullard, D. E., and D. D. Bigner. “Heterotransplantation of human craniopharyngiomas in athymic "nude" mice.Neurosurgery 4, no. 4 (April 1979): 308–14. https://doi.org/10.1227/00006123-197904000-00006.
Bullard DE, Bigner DD. Heterotransplantation of human craniopharyngiomas in athymic "nude" mice. Neurosurgery. 1979 Apr;4(4):308–14.
Bullard, D. E., and D. D. Bigner. “Heterotransplantation of human craniopharyngiomas in athymic "nude" mice.Neurosurgery, vol. 4, no. 4, Apr. 1979, pp. 308–14. Pubmed, doi:10.1227/00006123-197904000-00006.
Bullard DE, Bigner DD. Heterotransplantation of human craniopharyngiomas in athymic "nude" mice. Neurosurgery. 1979 Apr;4(4):308–314.
Journal cover image

Published In

Neurosurgery

DOI

ISSN

0148-396X

Publication Date

April 1979

Volume

4

Issue

4

Start / End Page

308 / 314

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Neurology & Neurosurgery
  • Neoplasm Transplantation
  • Middle Aged
  • Mice, Nude
  • Mice
  • Male
  • Humans
  • Female
  • Craniopharyngioma