Experimental chemotherapy of human medulloblastoma with classical alkylators.

Journal Article (Journal Article)

Seven classical alkylators were tested for activity against the continuous human medulloblastoma cell line TE-671 grown in vitro and as s.c. and intracranial xenografts in athymic mice. Drugs tested included melphalan, cyclophosphamide (4-hydroperoxycyclophosphamide in vitro), iphosphamide (4-hydroperoxyiphosphamide in vitro), phenylketocyclo-phosphamide, phenylketoiphosphamide, Asta Z 7557, and thiotriethyl-enephosphoramide. All agents were active, with melphalan demonstrating the most activity in vitro and in vivo. Comparative studies of cyclophosphamide and phenylketocyclophosphamide revealed partition coefficients (log P) of 0.73 and greater than 1.69, respectively, and cyclophosphamide exhibited greater cytotoxic activity in post- (equitoxic) drug administration murine plasma. Hematological toxicity was limited to leukopenia/neutropenia for both of these agents. These studies suggest that the classical alkylators may have a role in the treatment of medulloblastoma and provide a means to further analyze their therapeutic potential.

Full Text

Duke Authors

Cited Authors

  • Friedman, HS; Colvin, OM; Ludeman, SM; Schold, SC; Boyd, VL; Mulhbaier, LH; Bigner, DD

Published Date

  • June 1986

Published In

Volume / Issue

  • 46 / 6

Start / End Page

  • 2827 - 2833

PubMed ID

  • 3698009

International Standard Serial Number (ISSN)

  • 0008-5472


  • eng

Conference Location

  • United States