Chromosomal evolution in malignant human gliomas starts with specific and usually numerical deviations.

Journal Article (Journal Article)

Our previous karyotypic studies of malignant human gliomas have demonstrated that their most consistent early or primary gross changes include gains of #7, losses of #10, #22, and the gonosomes, and the presence of double minutes. Karyotypes of 15 additional malignant human gliomas reported here have confirmed these observations and, by enlarging our series, we can now show that in addition to double minutes, certain other gross structural abnormalities also are clearly associated with the early evolution of this type of tumor. The most prevalent deviations are deletions and translocations involving 9p. Other chromosomes commonly involved in rearrangements are #1, #6, and #13, and less frequently #7, #11, and #16.

Full Text

Duke Authors

Cited Authors

  • Bigner, SH; Mark, J; Bullard, DE; Mahaley, MS; Bigner, DD

Published Date

  • June 1986

Published In

Volume / Issue

  • 22 / 2

Start / End Page

  • 121 - 135

PubMed ID

  • 3011240

International Standard Serial Number (ISSN)

  • 0165-4608

Digital Object Identifier (DOI)

  • 10.1016/0165-4608(86)90172-x


  • eng

Conference Location

  • United States