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Vasoactive drugs produce selective changes in flow to experimental brain tumors.

Publication ,  Journal Article
Panther, LA; Baumbach, GL; Bigner, DD; Piegors, D; Groothuis, DR; Heistad, DD
Published in: Ann Neurol
December 1985

Most vasoactive drugs do not readily penetrate the blood-brain barrier and do not affect cerebral blood flow. We tested the hypothesis that vasoactive drugs may alter blood flow to brain tumors in which the blood-brain barrier is abnormal. Blood flow was measured with microspheres in dogs with brain tumors induced by avian sarcoma virus. Intravenously administered adenosine increased blood flow to tumor more than twofold but did not alter flow to normal brain. Intravenously administered norepinephrine decreased blood flow to tumor but not to normal brain. Thus, vasoactive drugs, which have little effect on blood flow to normal cerebrum, produce large changes in blood flow to brain tumors. We also examined responses to systemic hypercapnia. Hypercapnia increased blood flow to normal cerebrum more than twofold but failed to increase flow to tumors. Impaired vasodilator responses to hypercapnia in brain tumors, which cannot be explained primarily by an abnormality of the blood-brain barrier, probably reflect another fundamental difference between vessels in normal brain and brain tumors. The finding that vasoactive drugs have selective effects on blood flow to brain tumors has important implications for delivery of lipid-soluble chemotherapeutic drugs to the tumors.

Duke Scholars

Published In

Ann Neurol

DOI

ISSN

0364-5134

Publication Date

December 1985

Volume

18

Issue

6

Start / End Page

712 / 715

Location

United States

Related Subject Headings

  • Vasodilation
  • Sarcoma, Avian
  • Norepinephrine
  • Neurology & Neurosurgery
  • Dogs
  • Cerebrovascular Circulation
  • Carbon Dioxide
  • Brain Neoplasms
  • Blood-Brain Barrier
  • Animals
 

Citation

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Panther, L. A., Baumbach, G. L., Bigner, D. D., Piegors, D., Groothuis, D. R., & Heistad, D. D. (1985). Vasoactive drugs produce selective changes in flow to experimental brain tumors. Ann Neurol, 18(6), 712–715. https://doi.org/10.1002/ana.410180614
Panther, L. A., G. L. Baumbach, D. D. Bigner, D. Piegors, D. R. Groothuis, and D. D. Heistad. “Vasoactive drugs produce selective changes in flow to experimental brain tumors.Ann Neurol 18, no. 6 (December 1985): 712–15. https://doi.org/10.1002/ana.410180614.
Panther LA, Baumbach GL, Bigner DD, Piegors D, Groothuis DR, Heistad DD. Vasoactive drugs produce selective changes in flow to experimental brain tumors. Ann Neurol. 1985 Dec;18(6):712–5.
Panther, L. A., et al. “Vasoactive drugs produce selective changes in flow to experimental brain tumors.Ann Neurol, vol. 18, no. 6, Dec. 1985, pp. 712–15. Pubmed, doi:10.1002/ana.410180614.
Panther LA, Baumbach GL, Bigner DD, Piegors D, Groothuis DR, Heistad DD. Vasoactive drugs produce selective changes in flow to experimental brain tumors. Ann Neurol. 1985 Dec;18(6):712–715.
Journal cover image

Published In

Ann Neurol

DOI

ISSN

0364-5134

Publication Date

December 1985

Volume

18

Issue

6

Start / End Page

712 / 715

Location

United States

Related Subject Headings

  • Vasodilation
  • Sarcoma, Avian
  • Norepinephrine
  • Neurology & Neurosurgery
  • Dogs
  • Cerebrovascular Circulation
  • Carbon Dioxide
  • Brain Neoplasms
  • Blood-Brain Barrier
  • Animals