Comparative permeability of different glioma models to horseradish peroxidase.

Published

Journal Article

Seven different experimental glioma models were studied to determine their capillary permeability to horseradish peroxidase. The models were the autochthonous ASV-viral model, intracerebral (ic) and (sc) injections of rat 9L and RG-2 tumor cell lines, the sc rat S-69C15 tumor cell line, and human glioblastoma cell lines in nude mice. The ASV-viral model showed an average HRP permeability of 63% of tumor volume, the ic RG-2 tumors were 100% permeable, and the ic 9L tumors were 41% permeable. The permeability of the marginal zone (brain-tumor interface) showed similar variation from group to group. In contrast, all of the sc tumors were 100% permeable regardless of the cell line used to create the tumors. Our results show the variability between these glioma models, and suggest that RG-2 ic gliomas and all sc gliomas should be optimal to assess the tumoricidal effect of drugs, because access to the tumor compartment from the vascular compartment is complete.

Full Text

Duke Authors

Cited Authors

  • Groothuis, DR; Fischer, JM; Vick, NA; Bigner, DD

Published Date

  • 1981

Published In

Volume / Issue

  • 65 Suppl 2 /

Start / End Page

  • 13 - 18

PubMed ID

  • 6179614

Pubmed Central ID

  • 6179614

International Standard Serial Number (ISSN)

  • 0361-5960

Language

  • eng

Conference Location

  • United States