L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice.

Published

Journal Article

An intracranial (i.c.) interstitial radiotherapy model in athymic nude mice bearing i.c. D-54 MG human glioma xenografts was developed, allowing evaluation of the therapeutic benefits seen after L-buthionine-S,R-sulfoximine (L-BSO)-mediated depletion of tumor glutathione levels. Administration of L-BSO [2.5 mmol/kg intraperitoneal injections x 4 doses plus concomitant availability in acidified (pH 3.0) drinking water at a concentration of 20 mM] resulted in depletion of tumor glutathione levels to 0.15 mumol/g wet weight (7.9% of control). The therapeutic activity of i.c. interstitial radiotherapy with an 125I seed was enhanced after L-BSO-mediated glutathione depletion, with increases in median survival of 13.4 to 30.5% over that seen with 125I seeds alone. These studies demonstrate a potential role for BSO in enhancing the therapeutic activity of interstitial radiotherapy.

Full Text

Duke Authors

Cited Authors

  • Lippitz, BE; Halperin, EC; Griffith, OW; Colvin, OM; Honore, G; Ostertag, CB; Bigner, DD; Friedman, HS

Published Date

  • February 1990

Published In

Volume / Issue

  • 26 / 2

Start / End Page

  • 255 - 260

PubMed ID

  • 2308673

Pubmed Central ID

  • 2308673

International Standard Serial Number (ISSN)

  • 0148-396X

Digital Object Identifier (DOI)

  • 10.1097/00006123-199002000-00012

Language

  • eng

Conference Location

  • United States