R-type virus-like particles in avian sarcoma virus-induced rat central nervous system tumors.

Journal Article (Journal Article)

Morphologically distinct virus-like particles (VLP), similar to R-type VLP, were observed by electron microscopy in experimental rat central nervous system tumors induced with the B-77-C strain of avian sarcoma virus (ASV). R-type VLP have a characteristic internal radial structure and were observed previously only in hamster cells and in an established bovine cell line. They were not observed in the B-77 ASV inoculum used to induce the rat tumors or in the B-77 induced hamster glioma cells from which the B-77 was rescued. Nevertheless, the genome of an endogenous hamster R-type particle also might have been rescued and carried in the B-77 inoculum. Alternatively, R-type VLP may exist in a number of animal species, including the rat, and may be expressed in certain conditions such as neoplastic transformation.

Full Text

Duke Authors

Cited Authors

  • Cloyd, MW; Burger, PC; Bigner, DD

Published Date

  • June 1975

Published In

Volume / Issue

  • 54 / 6

Start / End Page

  • 1479 - 1482

PubMed ID

  • 166194

International Standard Serial Number (ISSN)

  • 0027-8874

Digital Object Identifier (DOI)

  • 10.1093/jnci/54.6.1479


  • eng

Conference Location

  • United States