Regional measurements of blood-to-tissue transport in experimental RG-2 rat gliomas.

Published

Journal Article

Regional measurements of blood-to-tissue transport were performed in transplanted RG-2 rat gliomas using [alpha- 14C]aminoisobutyric acid (AIB), quantitative autoradiography, and equations to express a unidirectional transfer constant. Thirty-eight intracranial tumors in ten rats were analyzed according to location; 23 intraparenchymal tumors, eight meningeal tumors, six fourth-ventricular tumors, and one third-ventricular tumor were studied. Except for the small third-ventricular tumor, the transfer constant (K) for AIB was similar in all groups and ranged from 0.031 to 0.038 ml/g/min. Within individual tumors, regional variation of K was also small, although some local variation could be correlated with histological features. The K for AIB decreased in brain around tumor and, at a distance of 300 microns from tumor edge, had returned to values similar to those of normal cortex (0.002 ml/g/min). An average extraction fraction (E) of 0.09 was calculated for AIB in the RG-2 tumors. The low E suggests that delivery of water-soluble chemotherapeutic drugs to RG-2 tumors should be limited more by capillary permeability or surface area than by blood flow. RG-2 is an ideal experimental tumor with which to test drug delivery and the methods that attempt to increase drug delivery in brain tumors.

Full Text

Duke Authors

Cited Authors

  • Groothuis, DR; Fischer, JM; Pasternak, JF; Blasberg, RG; Vick, NA; Bigner, DD

Published Date

  • July 1, 1983

Published In

Volume / Issue

  • 43 / 7

Start / End Page

  • 3368 - 3373

PubMed ID

  • 6850641

Pubmed Central ID

  • 6850641

International Standard Serial Number (ISSN)

  • 0008-5472

Language

  • eng

Conference Location

  • United States