In vivo measurement of regional brain tissue pH using positron emission tomography.

Journal Article (Journal Article)

Carbon-11-labeled dimethyloxazolidinedione ([11C]DMO) was injected intravenously into human subjects, and serial positron emission tomographic (PET) scans were obtained until brain-blood equilibration was achieved or could be accurately predicted from dynamic PET and 11C blood data. Knowledge of regional brain-blood partition coefficients for DMO, together with measurements of arterial blood hematocrit and pH, permitted the calculation of regional brain tissue and tumor pH (rpH). [11C]DMO PET rpH values were similar to rpH values derived from quantitative autoradiographic measurements of [14C]DMO concentrations in rat brain slices.

Full Text

Duke Authors

Cited Authors

  • Rottenberg, DA; Ginos, JZ; Kearfott, KJ; Junck, L; Bigner, DD

Published Date

  • 1984

Published In

Volume / Issue

  • 15 Suppl /

Start / End Page

  • S98 - 102

PubMed ID

  • 6611132

International Standard Serial Number (ISSN)

  • 0364-5134

Digital Object Identifier (DOI)

  • 10.1002/ana.410150718


  • eng

Conference Location

  • United States