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Therapeutic analysis of in vitro and in vivo brain tumor models.

Publication ,  Journal Article
Schuster, JM; Friedman, HS; Bigner, DD
Published in: Neurol Clin
May 1991

Virtually all brain tumor models studied to date have demonstrated the activity of the nitrosoureas, an observation confirmed in a cohort of adult patients with high-grade gliomas. However, studies with animal brain tumor models have not led to the selection of other clinically active agents (with the possible exception of AZQ), leading investigators to conduct experiments with human CNS tumor-derived cell lines and xenografts. These studies have identified agents subsequently shown to be active in phase II clinical trials against high-grade glioma and medulloblastoma. Clinical phase III trials in progress will demonstrate if these agents result in increased disease-free survival, which is the ultimate goal of all preclinical therapeutic studies. Future research with these laboratory models may ultimately allow the definition of the mechanisms of drug resistance and the identification of modulations effective in bypassing or reversing this resistance.

Duke Scholars

Published In

Neurol Clin

ISSN

0733-8619

Publication Date

May 1991

Volume

9

Issue

2

Start / End Page

375 / 382

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Neurology & Neurosurgery
  • Neoplasm Transplantation
  • Medulloblastoma
  • Humans
  • Glioma
  • Child
  • Cell Survival
  • Cell Line
  • Brain Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Schuster, J. M., Friedman, H. S., & Bigner, D. D. (1991). Therapeutic analysis of in vitro and in vivo brain tumor models. Neurol Clin, 9(2), 375–382.
Schuster, J. M., H. S. Friedman, and D. D. Bigner. “Therapeutic analysis of in vitro and in vivo brain tumor models.Neurol Clin 9, no. 2 (May 1991): 375–82.
Schuster JM, Friedman HS, Bigner DD. Therapeutic analysis of in vitro and in vivo brain tumor models. Neurol Clin. 1991 May;9(2):375–82.
Schuster, J. M., et al. “Therapeutic analysis of in vitro and in vivo brain tumor models.Neurol Clin, vol. 9, no. 2, May 1991, pp. 375–82.
Schuster JM, Friedman HS, Bigner DD. Therapeutic analysis of in vitro and in vivo brain tumor models. Neurol Clin. 1991 May;9(2):375–382.
Journal cover image

Published In

Neurol Clin

ISSN

0733-8619

Publication Date

May 1991

Volume

9

Issue

2

Start / End Page

375 / 382

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • Neurology & Neurosurgery
  • Neoplasm Transplantation
  • Medulloblastoma
  • Humans
  • Glioma
  • Child
  • Cell Survival
  • Cell Line
  • Brain Neoplasms