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Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria.

Publication ,  Journal Article
Heeney, MM; Ormsbee, SM; Moody, MA; Howard, TA; DeCastro, CM; Ware, RE
Published in: Mol Genet Metab
April 2003

Resistance to apoptosis has been described in neutrophils from patients with PNH and related hematologic disorders (aplastic anemia, myelodysplastic syndrome), but its molecular basis is not understood. Using gene expression analysis, PNH granulocytes had relative overexpression of four anti-apoptosis genes (human A1, hHR23B, Mcl-1, and RhoA) compared to normal controls. These findings were confirmed by RT-PCR analysis and observed in both peripheral blood granulocytes and mononuclear cells of patients with PNH. Anti-apoptosis gene upregulation may confer resistance to apoptosis in PNH and related disorders, and provide a common compensatory mechanism after bone marrow injury that allows survival and growth of remaining hematopoietic stem cells.

Duke Scholars

Published In

Mol Genet Metab

DOI

ISSN

1096-7192

Publication Date

April 2003

Volume

78

Issue

4

Start / End Page

291 / 294

Location

United States

Related Subject Headings

  • Up-Regulation
  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA
  • Leukocytes, Mononuclear
  • Humans
  • Hemoglobinuria, Paroxysmal
  • Hematopoietic Stem Cells
  • Granulocytes
  • Genetics & Heredity
  • Gene Expression
 

Citation

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Heeney, M. M., Ormsbee, S. M., Moody, M. A., Howard, T. A., DeCastro, C. M., & Ware, R. E. (2003). Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria. Mol Genet Metab, 78(4), 291–294. https://doi.org/10.1016/s1096-7192(03)00047-7
Heeney, Matthew M., Susan M. Ormsbee, M Anthony Moody, Thad A. Howard, Carlos M. DeCastro, and Russell E. Ware. “Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria.Mol Genet Metab 78, no. 4 (April 2003): 291–94. https://doi.org/10.1016/s1096-7192(03)00047-7.
Heeney MM, Ormsbee SM, Moody MA, Howard TA, DeCastro CM, Ware RE. Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria. Mol Genet Metab. 2003 Apr;78(4):291–4.
Heeney, Matthew M., et al. “Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria.Mol Genet Metab, vol. 78, no. 4, Apr. 2003, pp. 291–94. Pubmed, doi:10.1016/s1096-7192(03)00047-7.
Heeney MM, Ormsbee SM, Moody MA, Howard TA, DeCastro CM, Ware RE. Increased expression of anti-apoptosis genes in peripheral blood cells from patients with paroxysmal nocturnal hemoglobinuria. Mol Genet Metab. 2003 Apr;78(4):291–294.
Journal cover image

Published In

Mol Genet Metab

DOI

ISSN

1096-7192

Publication Date

April 2003

Volume

78

Issue

4

Start / End Page

291 / 294

Location

United States

Related Subject Headings

  • Up-Regulation
  • Reverse Transcriptase Polymerase Chain Reaction
  • RNA
  • Leukocytes, Mononuclear
  • Humans
  • Hemoglobinuria, Paroxysmal
  • Hematopoietic Stem Cells
  • Granulocytes
  • Genetics & Heredity
  • Gene Expression