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Xenon and the inflammatory response to cardiopulmonary bypass in the rat.

Publication ,  Journal Article
Clark, JA; Ma, D; Homi, HM; Maze, M; Grocott, HP
Published in: J Cardiothorac Vasc Anesth
August 2005

OBJECTIVE: The purpose of this study was to investigate the effect of xenon on the inflammatory response to cardiopulmonary bypass. DESIGN: Prospective, randomized experimental study. SETTING: University research laboratory. PARTICIPANTS: Sprague-Dawley rats. INTERVENTIONS: After surgical preparation, rats were randomly divided into 4 groups: (1) SHAM rats were cannulated but did not undergo cardiopulmonary bypass; (2) cardiopulmonary bypass rats were subjected to 60 minutes of cardiopulmonary bypass using an oxygenator receiving a 30% O(2), 65% N(2), and 5% CO(2) gas mixture; (3) MK801 rats received MK801 (0.15 mg/kg intravenous) 15 minutes before 60 minutes of cardiopulmonary bypass with the same gas mixture; and (4) xenon rats underwent 60 minutes of cardiopulmonary bypass receiving a 30% O(2), 60% xenon, 5% N(2), and 5% CO(2) gas mixture. MEASUREMENTS AND MAIN RESULTS: All bypass groups showed elevations in both cytokines compared with the SHAM-operated group. However, the inflammatory response to cardiopulmonary bypass in the group receiving xenon was no different from the other bypass groups. CONCLUSIONS: Xenon appears to have no effect on the inflammatory response to cardiopulmonary bypass, making its previously described neuroprotective effect during cardiopulmonary bypass likely independent of any inflammation modulation.

Duke Scholars

Published In

J Cardiothorac Vasc Anesth

DOI

ISSN

1053-0770

Publication Date

August 2005

Volume

19

Issue

4

Start / End Page

488 / 493

Location

United States

Related Subject Headings

  • Xenon
  • Rats, Sprague-Dawley
  • Rats
  • Random Allocation
  • Prospective Studies
  • Male
  • Inflammation
  • Disease Models, Animal
  • Cytokines
  • Cardiopulmonary Bypass
 

Citation

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Clark, J. A., Ma, D., Homi, H. M., Maze, M., & Grocott, H. P. (2005). Xenon and the inflammatory response to cardiopulmonary bypass in the rat. J Cardiothorac Vasc Anesth, 19(4), 488–493. https://doi.org/10.1053/j.jvca.2005.05.007
Clark, Jeffrey A., Daqing Ma, H Mayumi Homi, Mervyn Maze, and Hilary P. Grocott. “Xenon and the inflammatory response to cardiopulmonary bypass in the rat.J Cardiothorac Vasc Anesth 19, no. 4 (August 2005): 488–93. https://doi.org/10.1053/j.jvca.2005.05.007.
Clark JA, Ma D, Homi HM, Maze M, Grocott HP. Xenon and the inflammatory response to cardiopulmonary bypass in the rat. J Cardiothorac Vasc Anesth. 2005 Aug;19(4):488–93.
Clark, Jeffrey A., et al. “Xenon and the inflammatory response to cardiopulmonary bypass in the rat.J Cardiothorac Vasc Anesth, vol. 19, no. 4, Aug. 2005, pp. 488–93. Pubmed, doi:10.1053/j.jvca.2005.05.007.
Clark JA, Ma D, Homi HM, Maze M, Grocott HP. Xenon and the inflammatory response to cardiopulmonary bypass in the rat. J Cardiothorac Vasc Anesth. 2005 Aug;19(4):488–493.
Journal cover image

Published In

J Cardiothorac Vasc Anesth

DOI

ISSN

1053-0770

Publication Date

August 2005

Volume

19

Issue

4

Start / End Page

488 / 493

Location

United States

Related Subject Headings

  • Xenon
  • Rats, Sprague-Dawley
  • Rats
  • Random Allocation
  • Prospective Studies
  • Male
  • Inflammation
  • Disease Models, Animal
  • Cytokines
  • Cardiopulmonary Bypass