A novel chromosomal rearrangement associated with therapy-related acute leukemia.

Journal Article

We describe a 7-year-old girl with therapy-related acute myeloid leukemia (AML) associated with a single and novel karyotypic abnormality. The patient had been treated with alkylating agents and etoposide for hypothalamic pilocytic astrocytoma at age 17 months, and developed mixed lineage AML. Cytogenetic analysis of the leukemic blasts showed 46,XX,der(7)t(7;11)(q22;q14) in all cells examined. Southern blot analysis revealed three copies of an unrearranged MLL gene on chromosome 11q. This is the first report of a triplicated, unrearranged MLL gene in association with a deletion of 7q anomaly and an unbalanced translocation in therapy-related leukemia.

Full Text

Duke Authors

Cited Authors

  • Powell, J; Traweek, T; Beatty, O; Qumsiyeh, MB; Rosoff, PM

Published Date

  • July 15, 1999

Published In

Volume / Issue

  • 112 / 2

Start / End Page

  • 173 - 177

PubMed ID

  • 10686948

International Standard Serial Number (ISSN)

  • 0165-4608

Language

  • eng

Conference Location

  • United States