Increasing the intracellular Na+ concentration induces differentiation in a pre-B lymphocyte cell line.

Journal Article (Journal Article)

The ability of lipopolysaccharide (LPS), a polyclonal B-cell mitogen, to induce differentiation in the pre-B cell tumor line 70Z/3 can be mimicked by drugs that increase the intracellular Na+ concentration. Pharmacologically increasing the cellular Na+ content with monensin, a sodium ionophore, or ouabain, a specific inhibitor of Na+, K+-ATPase, induces surface IgM expression in these cells. We have shown that LPS stimulates uptake of Na+ through an amiloride-sensitive pathway. These results show that the essential action of LPS to induce surface IgM expression is activation of a Na+ uptake system.

Full Text

Duke Authors

Cited Authors

  • Rosoff, PM; Cantley, LC

Published Date

  • December 1, 1983

Published In

Volume / Issue

  • 80 / 24

Start / End Page

  • 7547 - 7550

PubMed ID

  • 6608724

Pubmed Central ID

  • PMC389989

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.80.24.7547


  • eng

Conference Location

  • United States