Role of MAP1B in axonal retrograde transport of mitochondria.


Journal Article

The MAPs (microtubule-associated proteins) MAP1B and tau are well known for binding to microtubules and stabilizing these structures. An additional role for MAPs has emerged recently where they appear to participate in the regulation of transport of cargos on the microtubules found in axons. In this role, tau has been associated with the regulation of anterograde axonal transport. We now report that MAP1B is associated with the regulation of retrograde axonal transport of mitochondria. This finding potentially provides precise control of axonal transport by MAPs at several levels: controlling the anterograde or retrograde direction of transport depending on the type of MAP involved, controlling the speed of transport and controlling the stability of the microtubule tracks upon which transport occurs.

Full Text

Duke Authors

Cited Authors

  • Jiménez-Mateos, E-M; González-Billault, C; Dawson, HN; Vitek, MP; Avila, J

Published Date

  • July 1, 2006

Published In

Volume / Issue

  • 397 / 1

Start / End Page

  • 53 - 59

PubMed ID

  • 16536727

Pubmed Central ID

  • 16536727

Electronic International Standard Serial Number (EISSN)

  • 1470-8728

Digital Object Identifier (DOI)

  • 10.1042/BJ20060205


  • eng

Conference Location

  • England