Triplet repeats form secondary structures that escape DNA repair in yeast.
Published
Journal Article
Several human neurodegenerative diseases result from expansion of CTG/CAG or CGG/CCG triplet repeats. The finding that single-stranded CNG repeats form hairpin-like structures in vitro has led to the hypothesis that DNA secondary structure formation is an important component of the expansion mechanism. We show that single-stranded DNA loops containing 10 CTG/CAG or CGG/CCG repeats are inefficiently repaired during meiotic recombination in Saccharomyces cerevisiae. Comparisons of the repair of DNA loops with palindromic and nonpalindromic sequences suggest that this inefficient repair reflects the ability of these sequences to form hairpin structures in vivo.
Full Text
Duke Authors
Cited Authors
- Moore, H; Greenwell, PW; Liu, CP; Arnheim, N; Petes, TD
Published Date
- February 16, 1999
Published In
Volume / Issue
- 96 / 4
Start / End Page
- 1504 - 1509
PubMed ID
- 9990053
Pubmed Central ID
- 9990053
International Standard Serial Number (ISSN)
- 0027-8424
Digital Object Identifier (DOI)
- 10.1073/pnas.96.4.1504
Language
- eng
Conference Location
- United States