Mutational analysis of the Drosophila DNA repair and recombination gene mei-9.

Journal Article (Journal Article)

Drosophila mei-9 is essential for several DNA repair and recombination pathways, including nucleotide excision repair (NER), interstrand crosslink repair, and meiotic recombination. To better understand the role of MEI-9 in these processes, we characterized 10 unique mutant alleles of mei-9. These include a P-element insertion that disrupts repair functions but not the meiotic function; three nonsense mutations, one of which has nearly wild-type levels of protein; three missense mutations, one of which disrupts the meiotic function but not repair functions; two small in-frame deletions; and one frameshift.

Full Text

Duke Authors

Cited Authors

  • Yildiz, O; Kearney, H; Kramer, BC; Sekelsky, JJ

Published Date

  • May 2004

Published In

Volume / Issue

  • 167 / 1

Start / End Page

  • 263 - 273

PubMed ID

  • 15166153

Pubmed Central ID

  • PMC1470841

International Standard Serial Number (ISSN)

  • 0016-6731

Digital Object Identifier (DOI)

  • 10.1534/genetics.167.1.263

Language

  • eng

Conference Location

  • United States