Mutational analysis of the Drosophila DNA repair and recombination gene mei-9.
Journal Article
Drosophila mei-9 is essential for several DNA repair and recombination pathways, including nucleotide excision repair (NER), interstrand crosslink repair, and meiotic recombination. To better understand the role of MEI-9 in these processes, we characterized 10 unique mutant alleles of mei-9. These include a P-element insertion that disrupts repair functions but not the meiotic function; three nonsense mutations, one of which has nearly wild-type levels of protein; three missense mutations, one of which disrupts the meiotic function but not repair functions; two small in-frame deletions; and one frameshift.
Full Text
Duke Authors
Cited Authors
- Yildiz, O; Kearney, H; Kramer, BC; Sekelsky, JJ
Published Date
- May 2004
Published In
Volume / Issue
- 167 / 1
Start / End Page
- 263 - 273
PubMed ID
- 15166153
Pubmed Central ID
- 15166153
International Standard Serial Number (ISSN)
- 0016-6731
Digital Object Identifier (DOI)
- 10.1534/genetics.167.1.263
Language
- eng
Conference Location
- United States