Tolerance and the "Holy Grail" of transplantation.
Publication
, Journal Article
Schroeder, RA; Marroquin, CE; Kuo, PC
Published in: J Surg Res
May 1, 2003
Advances in transplantation biology have greatly improved patient outcomes following transplant surgery. However, generalized immunosuppression remains the Achilles heel of modern transplantation surgery with its associated infectious and neoplastic morbidities. Tolerance remains the ultimate goal for the entire field. Although recent advances in transplant immunology suggest that tolerance may be achievable in the near future, the complex and redundant nature of the human immune system may not allow us to circumvent such a basic function as the recognition of nonself. In this paper, advances in transplant immunology are reviewed and their potential relevance to achieving the "Holy Grail" of transplantation are discussed.
Duke Scholars
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Published In
J Surg Res
DOI
ISSN
0022-4804
Publication Date
May 1, 2003
Volume
111
Issue
1
Start / End Page
109 / 119
Location
United States
Related Subject Headings
- Transplantation, Homologous
- Transplantation Immunology
- Transplantation Chimera
- Surgery
- Lymphocytes
- Immunosuppressive Agents
- Immune Tolerance
- Humans
- Histocompatibility Antigens Class II
- Histocompatibility Antigens Class I
Citation
APA
Chicago
ICMJE
MLA
NLM
Schroeder, R. A., Marroquin, C. E., & Kuo, P. C. (2003). Tolerance and the "Holy Grail" of transplantation. J Surg Res, 111(1), 109–119. https://doi.org/10.1016/s0022-4804(03)00081-7
Schroeder, Rebecca A., Carlos E. Marroquin, and Paul C. Kuo. “Tolerance and the "Holy Grail" of transplantation.” J Surg Res 111, no. 1 (May 1, 2003): 109–19. https://doi.org/10.1016/s0022-4804(03)00081-7.
Schroeder RA, Marroquin CE, Kuo PC. Tolerance and the "Holy Grail" of transplantation. J Surg Res. 2003 May 1;111(1):109–19.
Schroeder, Rebecca A., et al. “Tolerance and the "Holy Grail" of transplantation.” J Surg Res, vol. 111, no. 1, May 2003, pp. 109–19. Pubmed, doi:10.1016/s0022-4804(03)00081-7.
Schroeder RA, Marroquin CE, Kuo PC. Tolerance and the "Holy Grail" of transplantation. J Surg Res. 2003 May 1;111(1):109–119.
Published In
J Surg Res
DOI
ISSN
0022-4804
Publication Date
May 1, 2003
Volume
111
Issue
1
Start / End Page
109 / 119
Location
United States
Related Subject Headings
- Transplantation, Homologous
- Transplantation Immunology
- Transplantation Chimera
- Surgery
- Lymphocytes
- Immunosuppressive Agents
- Immune Tolerance
- Humans
- Histocompatibility Antigens Class II
- Histocompatibility Antigens Class I