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The emerging multifaceted roles of nitric oxide.

Publication ,  Journal Article
Kuo, PC; Schroeder, RA
Published in: Ann Surg
March 1995

Nitric oxide (NO) is a highly reactive free radical with a multitude of organ specific regulatory functions. Since 1985, NO has been the subject of numerous research efforts and as a result, has been found to play a major role in the cardiovascular, pulmonary, gastrointestinal, immune, and central nervous systems. In addition, deranged NO synthesis is the basis for a number of pathophysiologic states, such as atherosclerosis, pulmonary hypertension, pyloric stenosis, and the hypertension associated with renal failure. Traditional NO donors such as sodium nitroprusside and new pharmacologic NO adducts such as S-nitrosothiols may serve as exogenous sources of NO for the treatment of NO-deficient pathologic states. This review is an attempt to acquaint the surgical community with the fundamentals of NO biochemistry and physiology. Increased knowledge of its functions in normal homeostasis and pathologic states will enable physicians to better understand these disease processes and utilize new pharmacologic therapies.

Duke Scholars

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Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

March 1995

Volume

221

Issue

3

Start / End Page

220 / 235

Location

United States

Related Subject Headings

  • Surgery
  • Nitric Oxide
  • Lung
  • Inflammation
  • Immune System
  • Humans
  • Digestive System Physiological Phenomena
  • Central Nervous System
  • Cardiovascular Physiological Phenomena
  • 3202 Clinical sciences
 

Citation

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Kuo, P. C., & Schroeder, R. A. (1995). The emerging multifaceted roles of nitric oxide. Ann Surg, 221(3), 220–235. https://doi.org/10.1097/00000658-199503000-00003
Kuo, P. C., and R. A. Schroeder. “The emerging multifaceted roles of nitric oxide.Ann Surg 221, no. 3 (March 1995): 220–35. https://doi.org/10.1097/00000658-199503000-00003.
Kuo PC, Schroeder RA. The emerging multifaceted roles of nitric oxide. Ann Surg. 1995 Mar;221(3):220–35.
Kuo, P. C., and R. A. Schroeder. “The emerging multifaceted roles of nitric oxide.Ann Surg, vol. 221, no. 3, Mar. 1995, pp. 220–35. Pubmed, doi:10.1097/00000658-199503000-00003.
Kuo PC, Schroeder RA. The emerging multifaceted roles of nitric oxide. Ann Surg. 1995 Mar;221(3):220–235.

Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

March 1995

Volume

221

Issue

3

Start / End Page

220 / 235

Location

United States

Related Subject Headings

  • Surgery
  • Nitric Oxide
  • Lung
  • Inflammation
  • Immune System
  • Humans
  • Digestive System Physiological Phenomena
  • Central Nervous System
  • Cardiovascular Physiological Phenomena
  • 3202 Clinical sciences