The emerging multifaceted roles of nitric oxide.

Journal Article (Journal Article;Review)

Nitric oxide (NO) is a highly reactive free radical with a multitude of organ specific regulatory functions. Since 1985, NO has been the subject of numerous research efforts and as a result, has been found to play a major role in the cardiovascular, pulmonary, gastrointestinal, immune, and central nervous systems. In addition, deranged NO synthesis is the basis for a number of pathophysiologic states, such as atherosclerosis, pulmonary hypertension, pyloric stenosis, and the hypertension associated with renal failure. Traditional NO donors such as sodium nitroprusside and new pharmacologic NO adducts such as S-nitrosothiols may serve as exogenous sources of NO for the treatment of NO-deficient pathologic states. This review is an attempt to acquaint the surgical community with the fundamentals of NO biochemistry and physiology. Increased knowledge of its functions in normal homeostasis and pathologic states will enable physicians to better understand these disease processes and utilize new pharmacologic therapies.

Full Text

Duke Authors

Cited Authors

  • Kuo, PC; Schroeder, RA

Published Date

  • March 1995

Published In

Volume / Issue

  • 221 / 3

Start / End Page

  • 220 - 235

PubMed ID

  • 7717775

Pubmed Central ID

  • PMC1234563

International Standard Serial Number (ISSN)

  • 0003-4932

Digital Object Identifier (DOI)

  • 10.1097/00000658-199503000-00003


  • eng

Conference Location

  • United States